Role of Arsenic Trioxide in the Management of Aplastic Anemia

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
Gaurav PrakashPankaj Malhotra

Abstract

Aplastic anemia is a common problem in the developing world with therapeutic challenges as most of the patients are non-affording to standard care owing to resource constraints. We present the results of an open label single arm, non-randomized, single center, prospective phase II trial of the compassionate use of arsenic trioxide in patients refractory to ATG or unable to afford the standard of care therapy. The study was prematurely terminated at eighth week due to non-response in 100% of patients and death in two patients. The results are contradictory to what is already published and needs validation in a multicentric setting.

References

Nov 25, 2004·Hematology·Grover C BagbyCharles A Schiffer
Oct 16, 2012·Annals of Hematology·Quande LinBaijun Fang
Nov 3, 2012·British Journal of Haematology·Yongping SongBaijun Fang
Sep 21, 2013·Blood·Judith C W Marsh, Austin G Kulasekararaj
Mar 11, 2015·Journal of Public Health·Pankaj MalhotraSubhash Varma

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Citations

Dec 11, 2019·Current Pharmaceutical Biotechnology·Fatma Al Qahtani

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