PMID: 9179695Mar 1, 1997Paper

Role of ATP and related purine compounds on urethral relaxation in male rabbits

International Journal of Urology : Official Journal of the Japanese Urological Association
N OhnishiN Kajimoto

Abstract

Non-adrenergic, non-cholinergic (NANC) relaxation evoked by electrical field stimulation (EFS) has been observed in the urethra, with nitric oxide (NO) considered the agent most probably mediating this effect. However, Burnstock's purinergic hypothesis suggests that ATP and related purine compounds are neurotransmitters in NANC relaxation, although the physiological and pharmacological effects of ATP and related purine compounds in the urethra have been little studied. The effects of ATP and related purine compounds, NG-nitro-L-arginine (NOARG; an inhibitor of nitric oxide synthesis from L-arginine), calcitonin gene-related peptide (CGRP), substance P and vasoactive intestinal polypeptide (VIP) on relaxation and smooth muscle tension induced by electrical field stimulation (EFS) were studied in isolated male rabbit circular urethral smooth muscle (functional study). In addition, the outflow of ATP elicited by EFS was measured using the luciferase technique (superfusion study). All experiments were performed in the presence of guanethidine (3 x 10(-3) mol/L) and atropine (10(-6) mol/L). In preparations contracted with U46619, a prostaglandin peroxidase inhibitor, ATP had almost no effect on EFS-induced relaxation; however, suram...Continue Reading

References

Mar 1, 1977·Circulation Research·P J Kadowitz, A L Hyman
Mar 17, 1992·European Journal of Pharmacology·S HashimotoI Muramatsu
Jan 1, 1992·The Journal of Urology·K E AnderssonA Tøttrup
Jan 1, 1991·Acta Physiologica Scandinavica·K E AnderssonA Tøttrup
May 27, 1986·European Journal of Pharmacology·C H Hoyle, G Burnstock
Jul 15, 1988·Biochemical and Biophysical Research Communications·M KelmJ Schrader
Feb 1, 1988·British Journal of Pharmacology·P M Dunn, A G Blakeley
Sep 1, 1993·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·K KimuraS Kagawa
Feb 9, 1993·European Journal of Pharmacology·S HashimotoI Muramatsu

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Citations

Mar 30, 2010·Acta Physiologica·G BurnstockA Verkhratsky
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Sep 17, 2013·Neurourology and Urodynamics·Martin HennenbergChristian Gratzke
Jan 19, 2005·British Journal of Pharmacology·Christian PinnaGeoffrey Burnstock
Nov 17, 2005·BJU International·Viktoria Werkström, Karl-Erik Andersson
Dec 17, 2004·Pharmacological Reviews·Karl-Erik Andersson, Alan J Wein
Jun 6, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yojiro UkaiNoboru Toda

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