PMID: 2511037Oct 1, 1989Paper

Role of autologous lymph node T cells in membrane expression of mu- or gamma-heavy chain isotype by malignant B NHL cells

European Journal of Haematology
T BonnefoixJ J Sotto

Abstract

We investigated the possibility that T cells observed in lymph nodes involved by B-non-Hodgkin's lymphomas (B-NHL) may have a direct role in the expression of Mu- or Gamma- heavy chain isotype by autologous malignant B cells. T cells were separated from lymph nodes involved by B-NHL cells expressing either surface IgM (19 cases) or surface IgG (4 cases) and compared to peripheral blood T lymphocytes of healthy subjects (19 cases) for their ability to promote both IgG and IgM secretion in Cowan-activated normal B lymphocytes. The mean values of IgG/IgM ratios obtained under the influence of T cells associated with malignant B cells expressing either surface IgM or surface IgG were not statistically different to that obtained with the help of control T cells (0.60 and 0.62 versus 0.47, respectively). These results do not account for the hypothesis that autologous lymph node T cells may directly affect the expression of the heavy chain isotype by malignant B-NHL cells.

References

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T HiranoT Kishimoto
Feb 1, 1988·The Journal of Experimental Medicine·A MuraguchiT Kishimoto
Jul 1, 1988·European Journal of Immunology·S Bergstedt-LindqvistE Severinson
Jan 1, 1987·Immunology Today·J M Teale, K M Abraham

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