Role of Autophagy in Parkinson's Disease

Current Medicinal Chemistry
Silvia Cerri, Fabio Blandini

Abstract

Autophagy is an essential catabolic mechanism that delivers misfolded proteins and damaged organelles to the lysosome for degradation. Autophagy pathways include macroautophagy, chaperone-mediated autophagy and microautophagy, each involving different mechanisms of substrate delivery to lysosome. Defects of these pathways and the resulting accumulation of protein aggregates represent a common pathobiological feature of neurodegenerative disorders such as Alzheimer, Parkinson and Huntington disease. This review provides an overview of the role of autophagy in Parkinson's disease (PD) by summarizing the most relevant genetic and experimental evidence showing how this process can contribute to disease pathogenesis. Given lysosomes take part in the final step of the autophagic process, the role of lysosomal defects in the impairment of autophagy and their impact on disease will be also discuss. A glance on the role of non-neuronal autophagy in the pathogenesis of PD will be included. Moreover, we will examine novel pharmacological targets and therapeutic strategies that, by boosting autophagy, may be theoretically beneficial for PD. Special attention will be focused on natural products, such as phenolic compounds, that are receivin...Continue Reading

References

Aug 1, 1990·Trends in Biochemical Sciences·J F Dice
May 1, 1993·Journal of Neuropathology and Experimental Neurology·M S PollanenC Bergeron
Oct 8, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Oct 15, 1998·The New England Journal of Medicine·A E Lang, A M Lozano
Feb 24, 2001·Traffic·A M Cuervo, J F Dice
Jan 12, 2002·The American Journal of Pathology·Kurt ZatloukalHelmut Denk
Apr 30, 2003·The Journal of Biological Chemistry·Julie L WebbDavid C Rubinsztein
Jul 18, 2003·Journal of Neuroscience Research·Cristina Gómez-SantosSantiago Ambrosio
Oct 27, 2004·Cell and Tissue Research·Oliver von Bohlen Und Halbach
Feb 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Clifford W Shults
Feb 21, 2006·Lancet Neurology·K Ray ChaudhuriUNKNOWN National Institute for Clinical Excellence
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Richard A SteetStuart A Kornfeld
Dec 22, 2006·The Journal of Biological Chemistry·Sovan SarkarDavid C Rubinsztein
Sep 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Eva Andres-MateosValina L Dawson
Oct 3, 2007·Nature Cell Biology·Zhiping Xie, Daniel J Klionsky
Oct 12, 2007·Biochimie·Sophie PattingrePatrice Codogno
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Jan 10, 2008·Journal of Neurochemistry·Edward D PloweyCharleen T Chu
May 22, 2008·Biochemical and Biophysical Research Communications·He-Jin LeeSeung-Jae Lee
Jun 21, 2008·The Journal of Biological Chemistry·Tereza VogiatziLeonidas Stefanis
Nov 26, 2008·The Journal of Cell Biology·Derek NarendraRichard J Youle
Jun 12, 2009·Current Opinion in Cell Biology·Jean-Claude FarréMichael Thumm
Jun 27, 2009·Science·Marco SardielloAndrea Ballabio
Jul 10, 2009·Nature·David E HarrisonRichard A Miller
Aug 18, 2009·Nature Neuroscience·Luke S TainAlexander J Whitworth
Oct 7, 2009·The FEBS Journal·Udhaya Kumari, E K Tan
Oct 27, 2009·Autophagy·Päivi Ylä-AnttilaEeva-Liisa Eskelinen
Oct 28, 2009·Trends in Endocrinology and Metabolism : TEM·Ana Maria Cuervo
Nov 10, 2009·Nature Cell Biology·Mitsuko Hayashi-NishinoAkitsugu Yamamoto
Jan 9, 2010·Cell Death and Differentiation·S MichiorriG Casari
Jan 13, 2010·The Journal of Cell Biology·Wei-Lien YenDaniel J Klionsky
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cristina MalageladaLloyd A Greene
Jan 26, 2010·Nature Cell Biology·Sven GeislerWolfdieter Springer
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Elena ZivianiAlexander J Whitworth
Mar 23, 2010·Acta Neuropathologica·Thomas G BeachUNKNOWN Arizona Parkinson's Disease Consortium

❮ Previous
Next ❯

Citations

Dec 28, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Fabio BlandiniJosé L Lanciego
Aug 4, 2019·The Journal of Biological Chemistry·Jianqun GaoNicolas Dzamko
Sep 26, 2019·Current Medicinal Chemistry·Giacinto Bagetta, Damiana Scuteri
Nov 2, 2018·Current Medicinal Chemistry·Kyoung Sang ChoGyun Jee Song
Oct 28, 2019·Frontiers in Pharmacology·Zuqing SuGuangjuan Zheng
Sep 12, 2019·Frontiers in Aging Neuroscience·Büin AdamsEtheresia Pretorius
Jan 12, 2019·Neural Regeneration Research·Elisa PiscianzAnnalisa Marcuzzi
Sep 13, 2020·Experimental & Molecular Medicine·Doo Sin JoDong-Hyung Cho
Jan 11, 2019·BioMed Research International·Layana Karine F LimaMahendra Rai
Feb 11, 2019·Archives of Pharmacal Research·Doo Sin Jo, Dong-Hyung Cho
Jan 5, 2021·Frontiers in Neuroscience·Xiangpeng Ren, Jiang-Fan Chen
Jul 20, 2020·Neuroscience Letters·Hong JinChun-Feng Liu
Feb 19, 2021·Metabolic Brain Disease·Vandana ZamanNarendra L Banik
Apr 15, 2020·ACS Chemical Neuroscience·Annamarie B AllnuttVenkata Mahidhar Yenugonda
Mar 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Kaitlyn McGrathGabriela Caraveo
Mar 23, 2021·Frontiers in Aging Neuroscience·Melissa ScholefieldGarth J S Cooper
Jun 22, 2021·Journal of Parkinson's Disease·Meir Schechter, Ronit Sharon
Jun 5, 2021·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Ruili WangChen Li
Aug 15, 2021·Drug Metabolism and Personalized Therapy·Taiwo G Olubodun-ObadunOlufunmilayo O Adeyemi
Aug 21, 2021·Neurochemical Research·Huijie FanZhi Chai
Nov 9, 2021·Frontiers in Cell and Developmental Biology·Shiwei QiuYongyi Yuan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Alzheimer's Disease: Endosomes

Dysfunctional endosomal trafficking may be associated with Alzheimer’s disease (AD) pathology. Targeting the endosome may advance treatment options for AD. Here is the latest research on endosomes and AD.

Parkinson's Disease & Autophagy

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.