Abstract
To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1beta and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were significantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL-1beta+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori va...Continue Reading
References
Oct 11, 1992·Nucleic Acids Research·N AkopyanzD E Berg
Jul 1, 1971·Gut·G A GloberR Peto
Jul 28, 1995·The Journal of Biological Chemistry·J C AthertonT L Cover
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A CovacciN Figura
Oct 1, 1996·The American Journal of Surgical Pathology·M F DixonP Correa
Nov 1, 1996·The Journal of Applied Bacteriology·D G MarshallC J Smyth
Jun 3, 1998·Gastroenterology·J Q HuangR H Hunt
Dec 9, 1998·Helicobacter·Y YamaokaD Y Graham
Apr 6, 1999·Gut·D BassoM Plebani
Jun 12, 1999·Journal of Clinical Microbiology·Y YamaokaD Y Graham
Jun 26, 1999·Alimentary Pharmacology & Therapeutics·J Danesh
Sep 14, 1999·The American Journal of Gastroenterology·G D EslickN J Talley
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·M GerhardC Prinz
Apr 4, 2000·Nature·E M El-OmarC S Rabkin
Aug 21, 2001·Gut·UNKNOWN Helicobacter and Cancer Collaborative Group
Oct 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M ParkinS S Devesa
Mar 21, 2002·Nature Reviews. Cancer·Richard M Peek, Martin J Blaser
Jul 12, 2002·FEMS Immunology and Medical Microbiology·Abdussalam A R AshourCelso A de Oliveira
Aug 6, 2002·Cytokine·C-F ZambonM Plebani
Nov 21, 2002·Journal of the National Cancer Institute·Céu FigueiredoManuel Sobrinho-Simões
Nov 28, 2002·Gastroenterology·Il-Ran HwangYoshio Yamaoka
Mar 29, 2003·Journal of Clinical Pathology·C-F ZambonM Plebani
May 6, 2003·Gastroenterology·Emad M El-OmarWong-Ho Chow
Aug 2, 2003·Gastroenterology·José Carlos MachadoManuel Sobrinho-Simões
Apr 11, 1953·British Medical Journal·I AIRDJ A F ROBERTS
Nov 25, 2003·Gut·Z-R ZengJ J Y Sung
Nov 6, 2004·Journal of Clinical Microbiology·Farhana KauserNiyaz Ahmed
Aug 27, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chuen-Ming ShihLong-Yau Lin
Dec 20, 2005·Clinical and Experimental Medicine·W Alpízar-AlpízarR Sierra
Aug 26, 2006·Journal of Gastroenterology·Sergio A ConKeijiro Araki
Sep 1, 2007·Helicobacter·Sergio A ConTetsuro Sugiura
Oct 4, 2007·British Journal of Cancer·L Rosero-Bixby, R Sierra
Dec 19, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sergio A ConTetsuro Sugiura
Citations
Dec 25, 2012·Cancer Causes & Control : CCC·Ricardo L DominguezDouglas R Morgan
Dec 12, 2012·Cancer Causes & Control : CCC·Patricia BonequiM Constanza Camargo
Aug 4, 2012·PloS One·Huiping XueJing-Yuan Fang
Oct 11, 2012·PloS One·Ying ZhangQuanlin Feng
Sep 28, 2010·World Journal of Gastroenterology : WJG·Jian-Feng YiJun-Qiang Zhang
Jan 27, 2010·World Journal of Gastroenterology : WJG·Sergio A ConReinaldo Con-Wong
May 2, 2014·World Journal of Gastroenterology : WJG·Miguel Angel Chiurillo
May 17, 2014·World Journal of Gastroenterology : WJG·Camila A FigueiredoNeuza M Alcantara-Neves
Oct 18, 2011·Pharmacological Reports : PR·Aleksandra SałagackaEwa Balcerczak
Sep 21, 2013·Archives of Medical Research·Maura Ferrer-FerrerClas Une
Apr 19, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ivy Bastos RamisPedro Eduardo Almeida da Silva
Jul 3, 2009·Current Opinion in Pharmacology·Mairi H McLean, Emad M El-Omar
Dec 31, 2014·PloS One·Pengfei KongDazhi Xu
Jun 19, 2015·PloS One·Baoge QuGuangying Ren
May 4, 2018·The International Journal of Biological Markers·Mohammad Hossein Sahami-Fard
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xiong-Fei PanChun-Xia Yang
Aug 10, 2013·European Journal of Gastroenterology & Hepatology·Joana I MatosMário Dinis-Ribeiro
Aug 23, 2019·World Journal of Gastroenterology : WJG·Anca NegovanClaudia Bănescu
Apr 18, 2017·Gut Pathogens·Adolfo Román-RománGloria Fernández-Tilapa
May 26, 2020·BMC Cancer·Marce-Amara KpoghomouGuanfu Jin
Jun 6, 2021·The American Journal of the Medical Sciences·Wendy Malespín-BendañaVanessa Ramírez-Mayorga
Oct 26, 2021·Journal of Gastrointestinal Cancer·Mohammad ZareHossein Neamatzadeh