Role of bacterial and genetic factors in gastric cancer in Costa Rica.

World Journal of Gastroenterology : WJG
Sergio A ConReinaldo Con-Wong

Abstract

To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1beta and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were significantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL-1beta+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori va...Continue Reading

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Citations

Dec 25, 2012·Cancer Causes & Control : CCC·Ricardo L DominguezDouglas R Morgan
Dec 12, 2012·Cancer Causes & Control : CCC·Patricia BonequiM Constanza Camargo
Sep 28, 2010·World Journal of Gastroenterology : WJG·Jian-Feng YiJun-Qiang Zhang
Jan 27, 2010·World Journal of Gastroenterology : WJG·Sergio A ConReinaldo Con-Wong
May 17, 2014·World Journal of Gastroenterology : WJG·Camila A FigueiredoNeuza M Alcantara-Neves
Oct 18, 2011·Pharmacological Reports : PR·Aleksandra SałagackaEwa Balcerczak
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Aug 23, 2019·World Journal of Gastroenterology : WJG·Anca NegovanClaudia Bănescu
Jun 6, 2021·The American Journal of the Medical Sciences·Wendy Malespín-BendañaVanessa Ramírez-Mayorga

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