Abstract
The role of bacterial lipopolysaccharides (LPS) has been evaluated for their influence on the human T cell-mediated anti-Salmonella typhi activity. In nonendemic areas for salmonellosis this activity is exerted by CD4+ lymphocytes armed by IgA, whereas in endemic zones besides these cells also CD8+ lymphocytes armed by IgG display an elevated anti bacterial activity. These results suggest that, in endemic regions, continuous antigenic challenge and, in particular, that exerted by lipid A (the active moiety of LPS) may play a role in triggering this activity. In other series of experiments, pretreatment of endemic peripheral blood lymphocytes (PBL) with smooth and rough (Rb and Re) forms of Salmonella LPS leads to the inhibition of antibacterial activity. In this respect, Re-LPS, which contains lipid A covalently linked to the core-chetodeoxyoctonate, gives rise to the maximum of inhibition. Finally, fractionation of PBL by means of S. minnesota R345 (Rb) cytoadherence has led to the conclusion that anti bacterial activity is present in the Rb-unbound population, thus indicating that bacterial adherence to PBL is a distinct phenomenon from natural anti-S. typhi activity. The overall results suggest that lipid A is able to modula...Continue Reading
References
Jun 1, 1976·Scandinavian Journal of Immunology·M Jondal
Jan 1, 1989·Journal of Clinical Laboratory Analysis·C M MastroianniS Delia
May 1, 1988·American Journal of Reproductive Immunology and Microbiology : AJRIM·C De SimoneE Jirillo
May 1, 1986·Reviews of Infectious Diseases·R Edelman, M M Levine
May 1, 1985·Infection·E Jirillo, S Antonaci
Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby
Nov 10, 1983·Nature·A TagliabueD Boraschi
Citations
Jan 1, 1993·Mediators of Inflammation·M A Chirigos, C De Simone
Jan 1, 1993·Mediators of Inflammation·E JirilloS Antonaci
Mar 29, 2000·Immunopharmacology and Immunotoxicology·A B MaffioneE Jirillo
Aug 18, 2000·Immunopharmacology and Immunotoxicology·A PratelliC Buonavoglia
Oct 1, 1998·Scandinavian Journal of Gastroenterology·L AmatiE Jirillo
Apr 27, 2001·Immunopharmacology and Immunotoxicology·L AmatiE Jirillo
Jul 14, 2000·The American Journal of Gastroenterology·L CaradonnaD Caccavo
Apr 17, 1998·Immunopharmacology and Immunotoxicology·E JirilloO G Manghisi
Jan 22, 1998·Immunopharmacology and Immunotoxicology·M AltamuraE Jirillo
Jan 10, 2002·Journal of Clinical Gastroenterology·Maria AltamuraPietro Venezia
Aug 1, 1993·Immunopharmacology and Immunotoxicology·D De MattiaF Schettini
May 1, 1995·Immunopharmacology and Immunotoxicology·E JirilloO G Manghisi
Aug 1, 1996·Immunopharmacology and Immunotoxicology·E JirilloO G Manghisi
Mar 1, 1993·Immunopharmacology and Immunotoxicology·E JirilloV Covelli
Aug 1, 1993·Immunopharmacology and Immunotoxicology·V CovelliE Jirillo
Jul 1, 1995·Clinical and Diagnostic Laboratory Immunology·I MunnoE Paulling