Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma

BioMed Research International
Ming ChuYue-Dan Wang

Abstract

Baicalin (BA) is a flavonoid compound purified from Scutellaria baicalensis Georgi and has been shown to possess a potent inhibitory activity against viruses. However, the role of BA in anti-influenza virus has not been extensively studied, and the immunological mechanism of BA in antiviral activity remains unknown. Here, we observed that BA could protect mice from infection by influenza virus A/PR/8/34 (H1N1), associated with increasing IFN-γ production, but presented no effects in IFN-γ or IFN-γ receptor deficient mice. Further study indicated that BA could inhibit A/PR/8/34 replication through IFN-γ in human PBMC. Moreover, BA can directly induce IFN-γ production in human CD4(+) and CD8(+) T cells and NK cells, and activate JAK/STAT-1 signaling pathway. Collectively, BA exhibited anti-influenza virus A (H1N1) activity in vitro and in vivo as a potent inducer of IFN-γ in major IFN-γ producing cells.

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Citations

Jan 8, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ming ChuYue-Dan Wang
Nov 21, 2018·Journal of Cellular and Molecular Medicine·Yin-Siew LaiKo-Tung Chang
Jul 18, 2020·Medicinal Research Reviews·Zhi-Jun ZhangRong-Tao Li
Jun 3, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Ying JinDanping Zhao
May 27, 2017·Archives of Virology·Hovakim ZakaryanKeivan Zandi
Sep 11, 2020·The American Journal of Chinese Medicine·Shuang LiDong Shang
Sep 19, 2017·Biomedical Chromatography : BMC·Haiyan ZhuChenggang Huang
Nov 24, 2017·Cytogenetic and Genome Research·Baifen SongYudong Cui
Feb 12, 2020·Viruses·Salima Lalani, Chit Laa Poh
Sep 29, 2020·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Julia Solnier, Johannes-Paul Fladerer
Oct 30, 2020·Frontiers in Pharmacology·Ping GengXunlong Shi
Mar 7, 2021·Biomedicines·Natalya N BesednovaMikhail Yu Shchelkanov
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arumugam Vijaya AnandKuldeep Dhama
Jul 3, 2021·Pharmaceuticals·Patrícia I C GodinhoVera L M Silva
Aug 28, 2021·Current Microbiology·Vaishnavi ChandramouliWilson Aruni

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Methods Mentioned

BETA
PCR
electrophoresis
ELISA

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