Role of basic leucine zipper proteins in transcriptional regulation of the steroidogenic acute regulatory protein gene.

Molecular and Cellular Endocrinology
Pulak R MannaD M Stocco

Abstract

The regulation of steroidogenic acute regulatory protein (StAR) gene transcription by cAMP-dependent mechanisms occurs in the absence of a consensus cAMP response element (CRE, TGACGTGA). This regulation is coordinated by multiple transcription factors that bind to sequence-specific elements located approximately 150 bp upstream of the transcription start site. Among the proteins that bind within this region, the basic leucine zipper (bZIP) family of transcription factors, i.e. CRE binding protein (CREB)/CRE modulator (CREM)/activating transcription factor (ATF), activator protein 1 (AP-1; Fos/Jun), and CCAAT enhancer binding protein beta (C/EBPbeta), interact with an overlapping region (-81/-72 bp) in the StAR promoter, mediate stimulus-transcription coupling of cAMP signaling and play integral roles in regulating StAR gene expression. These bZIP proteins are structurally similar and bind to DNA sequences as dimers; however, they exhibit discrete transcriptional activities, interact with several transcription factors and other properties that contribute in their regulatory functions. The 5'-flanking -81/-72 bp region of the StAR gene appears to function as a key element within a complex cAMP response unit by binding to differe...Continue Reading

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Citations

Nov 20, 2010·Molecular Biology and Evolution·Arnau Sebé-PedrósIñaki Ruiz-Trillo
Mar 27, 2009·Molecular Human Reproduction·Pulak R MannaDouglas M Stocco
Apr 3, 2010·BMC Neuroscience·Sarah E London, David F Clayton
May 2, 2014·Journal of Molecular Endocrinology·Syed Kashif ZaidiSalman Azhar
Jun 4, 2011·Journal of Signal Transduction·Pulak R Manna, Douglas M Stocco
Dec 3, 2013·Human Pathology·Makoto EndoTorsten O Nielsen
Aug 15, 2015·Endocrine·Pulak R MannaKevin Pruitt
Dec 17, 2009·Insect Molecular Biology·R Lecanidou, A Papantonis
Aug 26, 2015·Mechanisms of Ageing and Development·Pulak R MannaDouglas M Stocco
Jul 2, 2010·Organogenesis·Rena Lecanidou, Argyris Papantonis
Nov 1, 2016·Molecular Reproduction and Development·Ahmed BulldanGeorgios Scheiner-Bobis
May 3, 2018·Biology of Reproduction·Vimal SelvarajBarbara J Clark
Mar 24, 2020·Genes and Immunity·Radomir M SlominskiAndrzej T Slominski

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