Role of Bassoon and Piccolo in Assembly and Molecular Organization of the Active Zone

Frontiers in Synaptic Neuroscience
E D GundelfingerC C Garner

Abstract

Bassoon and Piccolo are two very large scaffolding proteins of the cytomatrix assembled at the active zone (CAZ) where neurotransmitter is released. They share regions of high sequence similarity distributed along their entire length and seem to share both overlapping and distinct functions in organizing the CAZ. Here, we survey our present knowledge on protein-protein interactions and recent progress in understanding of molecular functions of these two giant proteins. These include roles in the assembly of active zones (AZ), the localization of voltage-gated Ca(2+) channels (VGCCs) in the vicinity of release sites, synaptic vesicle (SV) priming and in the case of Piccolo, a role in the dynamic assembly of the actin cytoskeleton. Piccolo and Bassoon are also important for the maintenance of presynaptic structure and function, as well as for the assembly of CAZ specializations such as synaptic ribbons. Recent findings suggest that they are also involved in the regulation activity-dependent communication between presynaptic boutons and the neuronal nucleus. Together these observations suggest that Bassoon and Piccolo use their modular structure to organize super-molecular complexes essential for various aspects of presynaptic fun...Continue Reading

References

Nov 1, 1996·Brain Research. Molecular Brain Research·K LangnaeseE D Gundelfinger
Aug 17, 1999·Current Opinion in Cell Biology·P Chavrier, B Goud
Nov 17, 1999·The European Journal of Neuroscience·J H BrandstätterH Wässle
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Apr 19, 2000·Nature Neuroscience·S E AhmariS J Smith
Jun 14, 2000·Current Opinion in Neurobiology·C C GarnerE D Gundelfinger
Apr 26, 2002·Trends in Neurosciences·Craig C GarnerNoam E Ziv
Jun 19, 2003·Molecular and Cellular Neurosciences·Thomas DresbachEckart D Gundelfinger
Dec 9, 2003·Trends in Biochemical Sciences·Markus Gruber, Andrei N Lupas
Jan 14, 2004·Nature Structural & Molecular Biology·Jesus GarciaJosep Rizo
Sep 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Henry HaeberleEllen A Lumpkin
Nov 25, 2004·Diabetes·Tadao ShibasakiSusumu Seino
Jun 14, 2005·Trends in Biochemical Sciences·Henry N Higgs
Jul 19, 2005·Annual Review of Neuroscience·Clarissa L WaitesCraig C Garner
Dec 21, 2005·Current Opinion in Cell Biology·David R Kovar
Feb 3, 2006·Molecular & Cellular Proteomics : MCP·Jonathan C TrinidadAlma L Burlingame
Feb 18, 2006·Trends in Cell Biology·Daniela CordaAlberto Luini
Jul 26, 2006·Cell and Tissue Research·Susanne Schoch, Eckart D Gundelfinger
Nov 23, 2006·Molecular & Cellular Proteomics : MCP·Richard P MuntonIsabelle M Mansuy
Dec 13, 2006·The European Journal of Neuroscience·Judyta JuranekReinhard Jahn
Jan 19, 2007·The European Journal of Neuroscience·Philippe RostaingSerge Marty
Mar 6, 2007·The International Journal of Biochemistry & Cell Biology·G Chinnadurai
Jun 29, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Léa SiksouSerge Marty
Jul 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qian CaiZu-Hang Sheng

❮ Previous
Next ❯

Citations

Jan 5, 2017·Cell Reports·Karina J VargasSreeganga S Chandra
Mar 11, 2017·Neuron·Dragomir Milovanovic, Pietro De Camilli
Dec 14, 2016·Scientific Reports·Hannah GrunerPedro Miura
Dec 2, 2017·The Journal of Physiology·Daniel ParthierChristoph Körber
Nov 10, 2017·Frontiers in Synaptic Neuroscience·Tanvi ButolaTobias Moser
Jul 5, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alberto CataneseTobias M Boeckers
Aug 2, 2018·Physiological Reviews·Tina PangrsicAlexandra Koschak
Nov 18, 2018·Canadian Journal of Physiology and Pharmacology·Akash K GeorgeMahavir Singh
Mar 7, 2019·Biology Open·Aileen RivellPamela J Yao
May 6, 2019·International Journal of Molecular Sciences·Rituparna Chakrabarti, Carolin Wichmann
May 11, 2019·ELife·Frauke AckermannCraig Curtis Garner
Aug 10, 2017·Scientific Reports·Sunil K SukumaranRobert F Margolskee
Aug 3, 2019·Physiological Reviews·Tobias MoserFrank Schmitz
Mar 24, 2017·Neural Plasticity·Viviana I TorresNibaldo C Inestrosa
Dec 19, 2019·Frontiers in Cellular Neuroscience·Daniela A GutierrezAlejandra R Alvarez
Jul 12, 2020·Cellular and Molecular Life Sciences : CMLS·Carolina Montenegro-VenegasAnna Fejtova
Aug 28, 2020·Frontiers in Synaptic Neuroscience·Georgii NosovJurgen Klingauf
Jul 8, 2017·Molecular Neurobiology·Viviana I Torres, Nibaldo C Inestrosa
Nov 6, 2018·Frontiers in Neuroanatomy·Tina Ghelani, Stephan J Sigrist
Jul 31, 2018·Frontiers in Neuroanatomy·Rebecca Wallrafen, Thomas Dresbach
Dec 6, 2019·Frontiers in Synaptic Neuroscience·Julio S Viotti, Thomas Dresbach
Apr 24, 2019·Nature Neuroscience·Benjamin SchattlingManuel A Friese
Jun 7, 2020·Journal of Molecular Neuroscience : MN·Yogesh Kumar Dhuriya, Divakar Sharma
Sep 11, 2019·Molecular Metabolism·Mica Ohara-ImaizumiToshihisa Ohtsuka
Nov 5, 2020·Cells·Florent GuillebaudJean-Denis Troadec
Jan 14, 2021·The Journal of Physiology·Martijn C SierksmaJ Gerard G Borst
Mar 12, 2020·Cell Reports·Pierre De RossiGopal Thinakaran
Feb 19, 2021·Human Molecular Genetics·Flora CozzolinoChiara Zuccato
Nov 7, 2021·Proceedings of the National Academy of Sciences of the United States of America·Shu HoPaïkan Marcaggi

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Methods Mentioned

BETA
X-ray
NMR
nucleotide exchange
ubiquitination

Software Mentioned

PyMOL

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