Role of bevacizumab in neoadjuvant chemotherapy and its influence on microvessel density in rectal cancer

International Journal of Clinical Oncology
Atsuki ArimotoMasato Nagino

Abstract

The role of bevacizumab (Bev) in neoadjuvant chemotherapy (NAC) without radiotherapy for rectal cancer has not been fully discussed. The purpose of this study is to assess the clinicopathological benefit of Bev in NAC for rectal cancer and to investigate its influence on microvessel status in cancerous tissue. Data on 47 patients with rectal cancer, who received NAC with or without Bev between August 2008 and November 2012, were analyzed retrospectively. The objective response was evaluated using the maximum tumor diameter. Tumor regression grade 3/4 was classified as a pathological response. Thirty-one patients (66 %) received NAC that included Bev and the other 16 patients were treated without Bev. The objective response rate was significantly higher in the Bev group than in the non-Bev group (64.5 vs. 25.0 %, p = 0.015). The rate of pathological response was much higher in the Bev group (41.9 %) than in the non-Bev group (12.5 %), but did not reach significant difference (p = 0.052). Microvessel density (MVD) in the resected cancerous tissue was significantly lower in the Bev group than in the non-Bev group. We have confirmed that objective and pathological responses were better in patients treated with NAC that included Bev...Continue Reading

References

Apr 17, 1997·Nature·W Risau
Jan 1, 1997·International Journal of Colorectal Disease·O DworakA Hoffmann
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathy D MillerHope S Rugo
Jun 18, 2005·Biochemical and Biophysical Research Communications·Napoleone FerraraWilliam Novotny
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200
Apr 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Leonard B SaltzJim Cassidy
Oct 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carmen J AllegraNorman Wolmark
Oct 19, 2010·Journal of Oncology·Adhemar Longatto FilhoFernando C Schmitt
Aug 2, 2011·Japanese Journal of Clinical Oncology·Keisuke UeharaMasato Nagino
Oct 18, 2011·International Journal of Clinical Oncology·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Oct 21, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuan-Yuan ZhaoLi Zhang
Nov 22, 2012·The Lancet Oncology·Jaafar BennounaUNKNOWN ML18147 Study Investigators
Jan 25, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Marcos Vinícius M de OliveiraAlfredo M B De Paula
Jan 15, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deborah SchragLeonard B Saltz

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Citations

Mar 13, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T KamiyaUNKNOWN Nagoya Surgical Oncology Group and the Chubu Clinical Oncology Group
May 1, 2021·Genes·Felicitas MungenastRupert C Ecker

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