Role of biologics and biosimilars in inflammatory bowel disease: current trends and future perspectives

Journal of Inflammation Research
Prashanth RawlaJeffrey Pradeep Raj

Abstract

Inflammatory bowel disease (IBD) is an idiopathic chronic inflammatory disease of the gastrointestinal system. The spectrum is of predominantly two types, namely, ulcerative colitis and Crohn's disease. The incidence of IBD has been increasing steadily since 1990, and so the number of agents used in their treatment. Biologics that are derived partly or completely from living biological sources such as animals and humans have become widely available, which provide therapeutic benefits to the IBD patients. Currently, monoclonal antibodies against tumor necrosis factor-alpha (infliximab, adalimumab, certolizumab, and golimumab), integrins (vedolizumab and natalizumab), and interleukin (IL)-12 and IL-23 antagonists (ustekinumab) are approved for use in IBD. Biosimilars of infliximab and adalimumab are also available for the treatment of IBD. This review summarizes the clinical pharmacology, studies leading to their approval, overall indications and their use in IBD, usage in pregnancy and lactation, and the adverse effects of these agents. This review also summarizes the recent advances and future perspectives specific to biologics and biosimilars in IBD.

Citations

Jul 20, 2019·Expert Review of Gastroenterology & Hepatology·Laurent Peyrin-BirouletTaegyun Kang
Nov 2, 2019·Inflammatory Bowel Diseases·Brindusa TrutaBashar Safar
Oct 28, 2019·Expert Review of Clinical Immunology·Ennio LubranoFabio Massimo Perrotta
Dec 13, 2019·Cost Effectiveness and Resource Allocation : C/E·Yazed AlRuthiaBander Balkhi
Mar 1, 2019·Transplantation·Sulemon ChaudhryAdam Griesemer
Jul 19, 2019·Drugs·Christopher MaVipul Jairath
Nov 14, 2019·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Vibeke StrandJohn D Isaacs
Aug 3, 2020·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Cynthia MorvilloSteven Stein
Apr 9, 2020·Frontiers in Immunology·Manuel O JakobChristoph S N Klose
May 12, 2020·World Journal of Gastroenterology : WJG·Tsvetelina Veselinova VelikovaSpaska Angelova Stanilova
May 6, 2020·World Journal of Clinical Cases·Ieva StundieneJonas Valantinas
Sep 27, 2018·World Journal of Gastroenterology : WJG·Joanna Sieczkowska-GolubJaroslaw Kierkus
Dec 24, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caroline M PercopoHelene F Rosenberg
Aug 28, 2019·Journal of Clinical Medicine·Iwona Krela-KaźmierczakAgnieszka Dobrowolska
Sep 14, 2020·Journal of Digestive Diseases·Saurabh Talathi, Kondal R Kyanam Kabir Baig
Oct 25, 2020·The Cochrane Database of Systematic Reviews·Cindy Cy LawNeeraj Narula
Oct 28, 2020·Expert Opinion on Biological Therapy·Rovshan M IsmailovZaytuna D Khasanova
Nov 20, 2020·Journal of Medical Economics·Eleonora Allocati, Brian Godman
Oct 6, 2020·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Tsen-Fang TsaiUNKNOWN Taiwan Rheumatology Association (TRA) and the Taiwanese Association for Psoriasis and Skin Immunology (TAPSI)
Nov 13, 2020·World Journal of Stem Cells·Rangnath MishraAmar B Singh
Mar 25, 2021·Current Allergy and Asthma Reports·Sendhilnathan Ramalingam, Ankoor Shah
Apr 11, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Neeraj NarulaWalter Reinisch
May 15, 2021·Canadian Journal of Gastroenterology & Hepatology·Anna Socha-BanasiakElżbieta Czkwianianc
May 15, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·D C R Fernandes, H J N Andreyev
Jun 22, 2021·Human Antibodies·Mariam BqainAngray S Kang
Aug 10, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xin LiYuefeng Rao
Jul 10, 2021·Journal of Clinical Gastroenterology·Mahnur Haider, Bret Lashner
Jan 1, 2022·Journal of Crohn's & Colitis·Apostolis PapaefthymiouStergios A Polyzos

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