Role of biomarker tests for diagnosis of neuroendocrine tumours

Nature Reviews. Endocrinology
Johannes HoflandWouter W de Herder

Abstract

Neuroendocrine tumours (NETs) are neoplasms that arise from neuroendocrine cells. Neuroendocrine cells and their tumours can secrete a wide range of amines and polypeptide hormones into the systemic circulation. This feature has triggered widespread investigation into circulating biomarkers for the diagnosis of NETs as well as for the prediction of the biological behaviour of tumour cells. Classic examples of circulating biomarkers for gastroenteropancreatic NETs include chromogranin A, neuron-specific enolase and pancreatic polypeptide as well as hormones that elicit clinical syndromes, such as serotonin and its metabolites, insulin, glucagon and gastrin. Biomarker metrics of general markers for diagnosing all gastroenteropancreatic NET subtypes are limited, but specific hormonal measurements can be of diagnostic value in select cases. In the past decade, methods for detecting circulating transcripts and tumour cells have been developed to improve the diagnosis of patients with NETs. Concurrently, modern scanning techniques and superior radiotracers for functional imaging have markedly expanded the options for clinicians dealing with NETs. Here, we review the latest research on biomarkers in the NET field to provide clinicians...Continue Reading

References

Aug 9, 1979·The New England Journal of Medicine·G J KrejsR H Unger
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L I LarssonJ R Rehfeld
Sep 1, 1986·The Journal of Clinical Endocrinology and Metabolism·I NorheimK Oberg
Dec 22, 1986·The American Journal of Medicine·J M Feldman, T M O'Dorisio
Jan 1, 1989·Acta Oncologica·B ErikssonE Wilander
Jan 3, 1985·The New England Journal of Medicine·S MelmedL A Frohman
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B WiedenmannV E Gould
Jul 31, 1986·The New England Journal of Medicine·T E AdrianS R Bloom
Jul 29, 1988·Journal of Chromatography·P M van Haard
Feb 1, 1970·Gut·D G Grahame-Smith
Oct 22, 1971·Science·G O Barbezat, M I Grossman
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·B L WajchenbergM A Kirschner
Jul 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E T JansonK Oberg
Jul 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H OrleforsB Eriksson
Oct 29, 1998·British Journal of Cancer·E BaudinM Schlumberger
Jan 9, 1999·Journal of Hepato-biliary-pancreatic Surgery·J Soga, Y Yakuwa
Apr 6, 1999·The American Journal of Medicine·A M DizonB J Hoogwerf
Aug 15, 2000·Digestion·B ErikssonM Stridsberg
Sep 22, 2000·The Journal of Clinical Endocrinology and Metabolism·B HirshbergP Gorden
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·F J Service, N Natt
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
Mar 29, 2001·European Journal of Radiology·J RickeB Wiedenmann
Oct 9, 2001·European Journal of Clinical Investigation·S SanduleanuR W Stockbrügger
Jan 5, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E SeregniE Bombardieri
Feb 5, 2002·Peptides·Eva Ekblad, Frank Sundler
Jan 1, 2003·Clinical Chemistry·Patrick M BossuytUNKNOWN Standards for Reporting of Diagnostic Accuracy
Feb 18, 2003·Endocrine Reviews·Leo J Hofland, Steven W J Lamberts
Jul 5, 2003·American Journal of Surgery·Kristine CalhounRodney Pommier
Mar 7, 1964·Lancet·J A OATESD T MASON

❮ Previous
Next ❯

Citations

Jan 5, 2019·Endocrine-related Cancer·Johannes HoflandWouter W de Herder
Jan 25, 2020·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·F JeuneS Gaujoux
Sep 27, 2019·Endocrine Reviews·Johannes HoflandWouter W de Herder
May 1, 2020·Scandinavian Journal of Gastroenterology·Jens F RehfeldLinda M Hilsted
May 7, 2019·The Journal of Clinical Endocrinology and Metabolism·Johannes HoflandPeter H Kann
Jun 2, 2020·World Journal of Gastroenterology : WJG·Zu-Yi MaBao-Hua Hou
Feb 6, 2020·Endocrine-related Cancer·Matthias BeyensKen Op de Beeck
Aug 26, 2020·Nature Reviews. Endocrinology·Guido Rindi, Bertram Wiedenmann
Jul 16, 2020·Journal of Clinical Medicine·Maria Isabel Del Olmo-GarcíaJuan-Francisco Merino-Torres
Aug 7, 2019·Cancers·Andrea SansoneMarialuisa Appetecchia
Jun 17, 2020·Frontiers in Oncology·Martine BocchiniMassimiliano Mazza
Sep 10, 2020·Journal of Clinical Medicine·Burcin ÖzdirikChristoph Roderburg
Jan 19, 2021·Acta Physiologica·Jens P GoetzeJens F Rehfeld
Jan 7, 2022·Abdominal Radiology·M J C van TreijenM E T Tesselaar
Nov 12, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gitta BoonsKen Op de Beeck

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
biopsy
PCR
NMR
imaging techniques

Software Mentioned

Octreoscan
NETest
CellSearch

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Italian Journal of Gastroenterology and Hepatology
K ObergBarbro Eriksson
Annals of Oncology : Official Journal of the European Society for Medical Oncology
Ettore SeregniE Bombardieri
Best Practice & Research. Clinical Gastroenterology
George Kanakis, Gregory Kaltsas
© 2022 Meta ULC. All rights reserved