Role of Blood-Brain Barrier in Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Zhiyou CaiQin Li

Abstract

The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer's disease (AD). BBB is a highly selective semipermeable structural and chemical barrier which ensures a stable internal environment of the brain and prevents foreign objects invading the brain tissue. BBB dysfunction induces the failure of Aβ transport from brain to the peripheral circulation across the BBB. Especially, decreased levels of LRP-1 (low density lipoprotein receptor-related protein 1) and increased levels of RAGE (receptor for advanced glycation endproducts) at the BBB can cause the failure of Aβ transport. The pathogenesis of AD is related to the BBB structural components, including pericytes, astrocytes, vascular endothelial cells, and tight junctions. BBB dysfunction will trigger neuroinflammation and oxidative stress, then enhance the activity of β-secretase and γ-secretase, and finally promote Aβ generation. A progressive accumulation of Aβ in brain and BBB dysfunction may become a feedback loop that gives rise to cognitive impairment and the onset of dementia. The correlation between BBB dysfunction and tau pathology has been well-reported. Therefore, regulating BBB function may be a new therapeutic target for treating AD.

References

Jul 1, 1986·Annals of Internal Medicine·W M PardridgeH J Frank
Oct 1, 1995·The Journal of Experimental Medicine·B SpellerbergE Tuomanen
Apr 21, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·M T CasertaD R Groothuis
Nov 18, 2000·American Journal of Physiology. Cell Physiology·R GiriV K Kalra
Aug 15, 2002·American Journal of Physiology. Cell Physiology·Ranjit GiriVijay K Kalra
Jun 23, 2004·Neurobiology of Disease·Praveen BallabhMaiken Nedergaard
Mar 31, 2005·Assay and Drug Development Technologies·Joseph H McCarty
May 26, 2005·Pharmacological Reviews·Brian T Hawkins, Thomas P Davis
Jun 25, 2005·Current Alzheimer Research·Robert D Moir, Rudolph E Tanzi
Aug 24, 2005·Nature Medicine·Zhenhua WuBerislav V Zlokovic
Jul 26, 2006·Acta Neuropathologica·John E DonahueEdward G Stopa
Nov 2, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert D BellBerislav V Zlokovic
Jul 20, 2007·Journal of Cellular and Molecular Medicine·Mihaela Oana RomanitanNenad Bogdanovic
Aug 19, 2007·Nature Medicine·Abhay SagareBerislav V Zlokovic
Feb 24, 2010·Current Medicinal Chemistry·M UenoH Sakamoto
Apr 24, 2010·Journal of Alzheimer's Disease : JAD·Scott E KanoskiTerry L Davidson
Sep 22, 2010·Clinical Pharmacology and Therapeutics·S OhtsukiT Terasaki
Mar 18, 2011·Neuro-degenerative Diseases·Jaume del ValleCarme Pelegrí
Sep 2, 2011·The Journal of Clinical Investigation·Markus KrohnJens Pahnke
Sep 9, 2011·Neuromolecular Medicine·Zhiyou CaiAnna Ratka
Oct 26, 2011·Current Neurovascular Research·Elodie VandenhauteMarie-Pierre Dehouck
Mar 7, 2012·Journal of Alzheimer's Disease : JAD·Tuan Minh DoFanchon Bourasset
Mar 13, 2012·The Journal of Clinical Investigation·Rashid DeaneBerislav V Zlokovic
Jun 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sun-Young KookInhee Mook-Jung
Jul 4, 2012·International Review of Neurobiology·Hari Shanker SharmaAruna Sharma
Aug 24, 2012·Journal of Alzheimer's Disease : JAD·Wan Adriyani W RuzaliSeth Love

❮ Previous
Next ❯

Citations

Jan 1, 2020·Biomolecules·Gabriela Dumitrita StanciuDaniela Carmen Ababei
Mar 25, 2020·Aging·Jack KellyXinzhong Li
Mar 7, 2019·Frontiers in Cellular Neuroscience·Duraisamy KempurajAsgar Zaheer
Oct 28, 2019·International Journal of Molecular Sciences·Anjana AjikumarJulie E Simpson
May 16, 2020·Frontiers in Neuroscience·Xing YuAnwen Shao
Apr 25, 2020·JAD Reports·Francis H C TsaoKeith C Meyer
Apr 9, 2020·International Journal of Molecular Sciences·Pasquale SimeoneRenato Mariani-Costantini
Mar 18, 2020·Fluids and Barriers of the CNS·Aditya BhaleraoLuca Cucullo
Sep 20, 2020·Pharmaceutics·Norwin KubickMichel-Edwar Mickael
Jun 15, 2019·Micromachines·Lili JiangHui Huang
Jan 31, 2020·Brain Communications·Oscar L LopezLewis H Kuller
Feb 1, 2021·Chemico-biological Interactions·Jiangping WeiDayue Darrel Duan
Feb 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad Shoaib TahirWei Zhang
Oct 27, 2020·Frontiers in Molecular Neuroscience·Alena MichalicovaAndrej Kovac
Mar 7, 2021·Molecular Neurobiology·Lei ZhangYu Deng
Mar 10, 2021·ACS Chemical Neuroscience·Ahmad SaitPhilip J R Day
Mar 7, 2021·International Journal of Molecular Sciences·Luis O Soto-RojasJosé Luna-Muñoz
Feb 20, 2021·European Journal of Pharmacology·Aihong YangRui Shen
Apr 20, 2021·Frontiers in Aging Neuroscience·Angelika Wiȩckowska-GacekUrszula Wojda
May 1, 2021·Microorganisms·Malena Dos Santos GuilhermeKristina Endres
May 4, 2021·Expert Review of Anti-infective Therapy·Ingar Olsen
Jun 21, 2021·Neuroscience Letters·Thomas A KimShaoyu Ge
Jul 22, 2021·Journal of Central Nervous System Disease·Immacolata VecchioMariamena Arbitrio
Jul 30, 2021·Frontiers in Aging Neuroscience·Meng Zhang, Zhigang Bian
Aug 7, 2021·Nature and Science of Sleep·Xiangyi Gu, Junchao Zhu
Aug 31, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·James A WisemanThomas I-H Park
Nov 11, 2020·Current Alzheimer Research·Agnieszka Kulczyńska-PrzybikBarbara Mroczko
Oct 8, 2021·BMC Neurology·Li-Jing ZhaoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 9, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Wei YinJinhao Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.