Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin, [15O]water, and [18F]fluoro-deoxy-glucose and positron emission tomography

The Journal of Clinical Investigation
P NuutilaH Yki-Järvinen

Abstract

Defects in insulin stimulation of blood flow have been used suggested to contribute to insulin resistance. To directly test whether glucose uptake can be altered by changing blood flow, we infused bradykinin (27 microgram over 100 min), an endothelium-dependent vasodilator, into the femoral artery of 12 normal subjects (age 25+/-1 yr, body mass index 22+/-1 kg/m2) after an overnight fast (n = 5) and during normoglycemic hyperinsulinemic (n = 7) conditions (serum insulin 465+/-11 pmol/liter, 0-100 min). Blood flow was measured simultaneously in both femoral regions using [15O]-labeled water ([15O]H2O) and positron emission tomography (PET), before and during (50 min) the bradykinin infusion. Glucose uptake was measured immediately after the blood flow measurement simultaneously in both femoral regions using [18F]-fluoro-deoxy-glucose ([18F]FDG) and PET. During hyperinsulinemia, muscle blood flow was 58% higher in the bradykinin-infused (38+/-9 ml/kg muscle x min) than in the control leg (24+/-5, P<0.01). Femoral muscle glucose uptake was identical in both legs (60.6+/-9.5 vs. 58.7+/-9.0 micromol/kg x min, bradykinin-infused vs control leg, NS). Glucose extraction by skeletal muscle was 44% higher in the control (2.6+/-0.2 mmol/l...Continue Reading

References

Jan 15, 1992·Biochemical and Biophysical Research Communications·R D FarhyA G Scicli
Jun 1, 1992·The Journal of Clinical Investigation·P NuutilaU Wegelius
Sep 1, 1991·The Journal of Clinical Endocrinology and Metabolism·A D BaronS V Edelman
Jun 1, 1991·The Journal of Clinical Investigation·E A AndersonA L Mark
Jul 1, 1987·The Journal of Clinical Investigation·H Yki-JärvinenC Bogardus
Oct 1, 1987·European Journal of Clinical Investigation·K W JauchG Dietze
Jun 1, 1987·The Journal of Clinical Investigation·H Yki-JärvinenJ E Foley
Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H IidaK Uemura
Mar 1, 1986·Biological Chemistry Hoppe-Seyler·K W JauchG Dietze
Aug 7, 1985·European Journal of Pharmacology·P D'Orléans-JusteD Regoli
Dec 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S Patlak, R G Blasberg
Oct 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·P RösenH Reinauer
Dec 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B E HowardP Freed
Aug 1, 1995·The Journal of Clinical Investigation·P NuutilaV A Koivisto
Feb 1, 1993·Journal of Cardiovascular Pharmacology·W D DachmanB B Hoffman
Oct 1, 1994·The Journal of Clinical Investigation·A NataliE Ferrannini
Dec 1, 1994·The Journal of Clinical Investigation·U ScherrerP Nicod
Aug 1, 1993·The Journal of Clinical Investigation·T A BuchananW Hsueh

❮ Previous
Next ❯

Citations

Feb 19, 1998·Zeitschrift für Ernährungswissenschaft·M J MüllerW Burchert
Mar 17, 2004·Microvascular Research·Kari K KalliokoskiPirjo Nuutila
Aug 4, 1997·The American Journal of Cardiology·W LinzB A Schölkens
Jun 12, 2003·Metabolism: Clinical and Experimental·William J DurhamRobert R Wolfe
Jun 14, 2001·Diabetes Research and Clinical Practice·M I WiggamP M Bell
May 7, 2010·The Journal of Antimicrobial Chemotherapy·Jussi SutinenHannele Yki-Järvinen
Jan 27, 1998·Current Opinion in Nephrology and Hypertension·C J TackT Thien
Oct 21, 2009·The Journal of Pharmacology and Experimental Therapeutics·Mias Pretorius, Nancy J Brown
May 26, 2011·American Journal of Physiology. Endocrinology and Metabolism·Eugene J BarrettZhenqi Liu
Jul 10, 2008·American Journal of Physiology. Endocrinology and Metabolism·Michael G Clark
Apr 23, 1999·Journal of Basic and Clinical Physiology and Pharmacology·J R Sowers, B Draznin
Apr 23, 1999·Journal of Basic and Clinical Physiology and Pharmacology·J W Kolaczynski, J F Caro
Mar 7, 2014·The Journal of Endocrinology·Louis PotierUNKNOWN DESIR Study Group
Sep 16, 2014·Trends in Cardiovascular Medicine·Lina ZhaoZhenqi Liu
May 20, 1998·Clinical Therapeutics·Z T Bloomgarden
May 20, 1998·Clinical and Experimental Pharmacology & Physiology·S J ClelandJ M Connell
Nov 4, 2000·Expert Opinion on Investigational Drugs·R Komers, K Komersova
Mar 31, 2012·The Journal of Surgical Research·Hongzhi XuAlan J Fischman
May 25, 2010·Clinical Physiology and Functional Imaging·Marko S LaaksonenKari K Kalliokoski
Mar 22, 2014·Annals of the New York Academy of Sciences·Camila ManriqueJames R Sowers
Jul 18, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·K N Frayn
Feb 13, 2003·Obesity Research·Kirsti HällstenPirjo Nuutila
Apr 24, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Abeer M MahmoudJacob M Haus
Feb 19, 2000·Annals of Medicine·J Knuuti, P Nuutila
Jan 30, 2004·Diabetes·Lei ZhangEugene J Barrett
Jul 19, 2016·Bioscience, Biotechnology, and Biochemistry·Akiko InagakiYasuko Manabe
Nov 1, 2016·Clinical and Experimental Pharmacology & Physiology·Michelle A KeskeStephen Rattigan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.