Role of blood pressure in mediating the influence of salt intake on renin expression in the kidney

American Journal of Physiology. Renal Physiology
K MachuraA Kurtz

Abstract

The salt intake of an organism controls the number of renin-producing cells in the kidney by yet undefined mechanisms. This study aimed to assess a possible mediator role of preglomerular blood pressure in the control of renin expression by oral salt intake. We used wild-type (WT) mice and mice lacking angiotensin II type 1a receptors (AT(1a)-/-) displaying an enhanced salt sensitivity to renin expression. In WT kidneys, we found renin-expressing cells at the ends of all afferent arterioles. A low-salt diet (0.02%) led to a moderate twofold increase in renin-expressing cells along afferent arterioles. In AT(1a)-/- mice, lowering of salt content led to a 12-fold increase in renin expression. Here, the renin-expressing cells were distributed along the preglomerular vascular tree in a typical distal-to-proximal distribution gradient which was most prominent at high salt intake and was obliterated at low salt intake by the appearance of renin-expressing cells in proximal parts of the preglomerular vasculature. While lowering of salt intake produced only a small drop in blood pressure in WT mice, the marked reduction of systolic blood pressure in AT(1a)-/- mice was accompanied by the disappearance of the distribution gradient from a...Continue Reading

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Citations

May 12, 2012·Pflügers Archiv : European journal of physiology·Sean T GlennLi Pan
Jun 27, 2012·Pflügers Archiv : European journal of physiology·Ulla G FriisBoye L Jensen
Mar 21, 2013·European Journal of Clinical Nutrition·G K PalD Amudharaj
Sep 23, 2014·Pflügers Archiv : European journal of physiology·Katharina MachuraLisa Kurtz
Dec 17, 2014·Pflügers Archiv : European journal of physiology·Frank Schweda
Feb 20, 2018·Pflügers Archiv : European journal of physiology·Christian KargerArmin Kurtz
Jun 27, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lucie K XaTimothy L Reudelhuber
Jun 19, 2017·Pflügers Archiv : European journal of physiology·Armin Kurtz
Jan 23, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Birgül Kurt, Armin Kurtz
Nov 29, 2013·American Journal of Physiology. Renal Physiology·Birgül KurtArmin Kurtz
Dec 5, 2021·The Journal of Physiology·Katharina A E BroekerArmin Kurtz

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