Role of bone marrow-derived mesenchymal stem cells in the prevention of hyperoxia-induced lung injury in newborn mice

Cell Biology International
Xiaoying ZhangZhichun Feng

Abstract

BPD (bronchopulmonary dysplasia) is predominantly characterized by persistent abnormalities in lung structure and arrested lung development, but therapy can be palliative. While promising, the use of BMSC (bone marrow-derived mesenchymal stem cell) in the treatment of lung diseases remains controversial. We have assessed the therapeutic effects of BMSC in vitro and in vivo. In vitro co-culturing with injured lung tissue increased the migration-potential of BMSC; and SP-C (surfactant protein-C), a specific marker of AEC2 (type II alveolar epithelial cells), was expressed. Following intraperitoneal injection of BMSC into experimental BPD mice on post-natal day 7, it was found that BMSC can home to the injured lung, express SP-C, improve pulmonary architecture, attenuate pulmonary fibrosis and increase the survival rate of BPD mice. This work supports the notion that BMSC are of therapeutic benefit through the production of soluble factors at bioactive levels that regulate the pathogenesis of inflammation and fibrosis following hyperoxia.

References

Jun 18, 2005·American Journal of Respiratory Cell and Molecular Biology·Jacqueline C ChangAlan Fine
Jun 17, 2006·Stem Cells·Gaël Y RochefortJorge Domenech
Apr 3, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hidehiko NakanishiJesse D Roberts
Jun 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Luis A OrtizDonald G Phinney
May 28, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaoying ZhangShuhan Sun
Aug 29, 2009·American Journal of Respiratory and Critical Care Medicine·Timothy van HaaftenBernard Thébaud
Sep 8, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Keith D SalazarArnold R Brody
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·William R HendersonMichael Kahn

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Citations

Aug 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Marcel F NoldClaudia A Nold-Petry
Oct 16, 2013·Pediatric Research·Moses E Fung, Bernard Thébaud
May 21, 2013·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Ludwig GortnerErol Tutdibi
Sep 3, 2013·Clinical and Experimental Medicine·Yun LuanFeng Kong
Dec 20, 2013·Antioxidants & Redox Signaling·Jennifer J P Collins, Bernard Thébaud
Nov 4, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Kajsa Bohlin
Feb 13, 2016·Molecular and Cellular Pediatrics·Martin MuellerBoris W Kramer
Jan 19, 2016·Seminars in Perinatology·S Alex Mitsialis, Stella Kourembanas
Mar 2, 2016·The International Journal of Biochemistry & Cell Biology·Mandy LaubeClaire Fabian
Jan 16, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kenneth SinclairDaniel C Chambers
Mar 1, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Vineet Bhandari
Mar 13, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jennifer J P Collins, Bernard Thébaud
Jun 13, 2015·British Medical Bulletin·Collin T StablerPeter I Lelkes
Aug 19, 2015·Frontiers in Medicine·Marius A Möbius, Bernard Thébaud
Mar 26, 2015·Indian Journal of Pediatrics·Ciprian P Gheorghe, Vineet Bhandari
Jul 19, 2016·Paediatric Respiratory Reviews·Marius Alexander Möbius, Bernard Thébaud
Oct 23, 2016·Cell and Tissue Research·Megan O'Reilly, Bernard Thébaud
Mar 10, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Flore LesageJan Deprest
Jan 30, 2014·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Danielle Niver
Mar 1, 2014·Birth Defects Research. Part A, Clinical and Molecular Teratology·Deepak Jain, Eduardo Bancalari
Jan 6, 2019·Bioscience Reports·Xing-Liang FanQing-Ling Fu
Apr 26, 2013·Current Opinion in Pediatrics·Peter M Mourani, Steven H Abman
Sep 6, 2019·Cell Biology and Toxicology·Miquéias Lopes-PachecoPaolo Pelosi
Dec 5, 2013·Current Opinion in Critical Care·Tatiana Maron-GutierrezPatricia R M Rocco
Oct 12, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jessica Berger, Vineet Bhandari
Mar 31, 2018·Oxidative Medicine and Cellular Longevity·Lei ZhangLin Wang
Jul 23, 2013·Annals of the American Thoracic Society·Daniel J WeissDarwin Prockop
Aug 2, 2018·European Journal of Pediatrics·Anoop PahujaAnne Greenough
May 24, 2020·Journal of Clinical Medicine·Luca BonadiesEugenio Baraldi
May 17, 2018·Stem Cells International·Judith GronbachHarald Ehrhardt
Nov 12, 2020·International Journal of Molecular Sciences·Jae-Sung RyuYoung-Kug Choo
Jan 28, 2021·International Journal of Molecular Sciences·Maurizio J GoetzHarald Ehrhardt

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