Role of bone morphogenetic protein 4 in the differentiation of brown fat-like adipocytes

American Journal of Physiology. Endocrinology and Metabolism
Rui-Dan XueYi-Ming Li

Abstract

There are two different types of fat present in mammals: white adipose tissue, the primary site of energy storage, and brown adipose tissue, which is specializes in energy expenditure. Factors that specify the developmental fate and function of brown fat are poorly understood. Bone morphogenic proteins (BMPs) play an important role in adipogenesis. While BMP4 is capable of triggering commitment of stem cells to the white adipocyte lineage, BMP7 triggers commitment of progenitor cells to a brown adipocyte lineage and activates brown adipogenesis. To investigate the differential effects of BMPs on the development of adipocytes, C3H10T1/2 pluripotent cells were pretreated with BMP4 and BMP7, followed by different adipogenic induction cocktails. Both BMP4 and BMP7 unexpectedly activated a full program of brown adipogenesis, including induction of the brown fat-defining marker uncoupling protein-1 (UCP1), increasing the expression of early regulators of brown fat fate PRDM16 (PR domain-containing 16) and induction of mitochondrial biogenesis and function. Implantation of BMP4-pretreated C3H10T1/2 cells into nude mice resulted in the development of adipose tissue depots containing UCP1-positive brown adipocytes. Interestingly, BMP4 c...Continue Reading

References

Mar 12, 1968·Biochemical and Biophysical Research Communications·S B PrusinerO Lindberg
Dec 1, 1984·The Journal of Nutrition·O L Tulp, P P Krupp
Mar 2, 1999·Biochemical and Biophysical Research Communications·Y IrieM Saito
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·A Hernández, M J Obregón
Jan 23, 2003·Genome Biology·Amalia LedesmaEduardo Rial
Aug 20, 2003·The Journal of Bone and Joint Surgery. American Volume·Hongwei ChengTong-Chuan He
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Qi-Qun TangM Daniel Lane
Aug 30, 2005·Critical Reviews in Biochemistry and Molecular Biology·Tamara C Otto, M Daniel Lane
Aug 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert R BowersM Daniel Lane
Feb 23, 2007·Cell Cycle·Robert R Bowers, M Daniel Lane
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·James A TimmonsBarbara Cannon
Oct 25, 2007·Cell·Stephane GestaC Ronald Kahn
Aug 23, 2008·Nature·Patrick SealeBruce M Spiegelman
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Haiyan HuangQi-Qun Tang
Nov 10, 2009·Cytokine & Growth Factor Reviews·Tim J Schulz, Yu-Hua Tseng
Sep 24, 2010·Drug News & Perspectives·Cecile VernochetStephen R Farmer
Dec 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Tim J SchulzYu-Hua Tseng
Dec 24, 2010·The Journal of Experimental Biology·Barbara Cannon, Jan Nedergaard
Aug 11, 2011·American Journal of Physiology. Endocrinology and Metabolism·Tomas B WaldénJan Nedergaard
Oct 11, 2011·Cell Metabolism·Dyan SellayahDevanjan Sikder
Jan 10, 2012·The International Journal of Biochemistry & Cell Biology·Angeliki MargoniAthanasios G Papavassiliou
Feb 4, 2012·Genes & Development·Ffolliott M FisherBruce M Spiegelman
Jan 4, 2013·Stem Cells Translational Medicine·Elizabeth A SalisburyElizabeth A Olmsted-Davis
Feb 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Shu-Wen QianQi-Qun Tang

❮ Previous
Next ❯

Citations

May 6, 2016·Frontiers in Endocrinology·Sung Sik ChoeJae Bum Kim
Mar 13, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S WangM Du
Mar 6, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Jiyoung BaeLing Zhao
Jul 5, 2016·International Journal of Molecular Sciences·Francisco Javier Ruiz-OjedaConcepción María Aguilera
Aug 16, 2016·Cell Reports·Salvatore ModicaChristian Wolfrum
Nov 4, 2016·Nature Reviews. Endocrinology·Francesc VillarroyaMarta Giralt
Nov 11, 2016·Calcified Tissue International·Nicolas Bonnet
Jan 21, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P BaskaranB Thyagarajan
Jan 5, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Ana M Blázquez-MedelaKristina I Boström
Jan 4, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Darija ŠnajderRadivoje Radić
Oct 7, 2017·NPJ Systems Biology and Applications·Elin NymanGunnar Cedersund
Jun 3, 2018·Hormones : International Journal of Endocrinology and Metabolism·Charikleia StefanakiGeorge P Chrousos
Aug 14, 2019·Molecular Biology Reports·Mikako MotomuraMasayuki Funaba
Jan 31, 2020·Stem Cell Research & Therapy·Sheng-Nan Li, Jia-Fa Wu
Aug 28, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Andrew C McMillan, Matthew D White
Jun 19, 2019·Journal of Lipid Research·Jan-Bernd Funcke, Philipp E Scherer
Feb 12, 2017·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T MontanariM Colitti
Jun 21, 2020·International Journal of Molecular Sciences·Melvin A AmbeleMichael S Pepper
Jun 23, 2019·Molecular Aspects of Medicine·Joseph D WhiteKristin I Stanford
Feb 3, 2021·Cell Biochemistry and Function·Huong Giang PhamJong Won Yun
Jan 12, 2021·Frontiers in Endocrinology·Magdalena LeivaGuadalupe Sabio
Apr 20, 2021·The Journal of Biological Chemistry·Shuwen QianQi-Qun Tang
Jul 1, 2020·Molecular and Cellular Endocrinology·Ruya LiuKe Ma
Jul 10, 2021·Frontiers in Cell and Developmental Biology·Yuxuan ZhongJun Fan
Jul 15, 2021·Journal of Diabetes Research·Yao ChenShen Qu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

American Journal of Physiology. Cell Physiology
Manuela ElsenJürgen Eckel
Proceedings of the National Academy of Sciences of the United States of America
Qi-Qun TangM Daniel Lane
Proceedings of the National Academy of Sciences of the United States of America
Shu-Wen QianQi-Qun Tang
© 2021 Meta ULC. All rights reserved