Role of bradykinin B1 and B2 receptors in normal blood pressure regulation

American Journal of Physiology. Endocrinology and Metabolism
Arvi DukaH Gavras

Abstract

With inhibition or absence of the bradykinin B2 receptor (B2R), B1R is upregulated and assumes some of the hemodynamic properties of B2R, indicating that both participate in the maintenance of normal vasoregulation or to development of hypertension. Herein we further evaluate the role of bradykinin in normal blood pressure (BP) regulation and its relationship with other vasoactive factors by selectively blocking its receptors. Six groups of Wistar rats were treated for 3 wk: one control group with vehicle alone, one with concurrent administration of B1R antagonist R-954 (70 microg x kg(-1) x day(-1)) and B2R antagonist HOE-140 (500 microg x kg(-1) x day(-1)), one with R-954 alone, one with HOE 140 alone, one with concurrent administration of both R-954 and HOE-140 plus the angiotensin antagonist losartan (5 mg x kg(-1) x day(-1)), and one with only losartan. BP was measured continuously by radiotelemetry. Only combined administration of B1R and B2R antagonists produced a significant BP increase from a baseline of 107-119 mmHg at end point, which could be partly prevented by losartan and was not associated with change in catecholamines, suggesting no involvement of the sympathoadrenal system. The impact of blockade of bradykinin...Continue Reading

References

Jul 23, 1991·European Journal of Pharmacology·G BaoT Unger
Sep 1, 1991·Hypertension·O A Carretero, A G Scicli
Jan 1, 1985·The American Journal of Physiology·J P Granger, J E Hall
Apr 24, 1981·European Journal of Pharmacology·D C RegoliJ Lavigne
Jan 1, 1995·Annual Review of Pharmacology and Toxicology·J V Mombouli, P M Vanhoutte
Oct 1, 1995·Clinical and Experimental Hypertension : CHE·N A RuoccoH Gavras
Jul 25, 1996·Biochemical and Biophysical Research Communications·M E AlfieO A Carretero
Oct 8, 1999·The Journal of Clinical Investigation·Y TsutsumiT Iwasaka
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J B PesqueroM Bader
Dec 26, 2001·Hypertension·I DukaH Gavras
May 25, 2002·Canadian Journal of Physiology and Pharmacology·Witold NeugebauerFernand Gobeil
Sep 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·D A BradburyA J Knox
Feb 28, 2003·Journal of Molecular and Cellular Cardiology·Robert M Bell, Derek M Yellon
Oct 15, 2003·Hypertension·Irena DukaHaralambos Gavras
Dec 24, 2003·Hypertension·Wendy W BatenburgA H Jan Danser

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Citations

Dec 22, 2006·The Journal of Pharmacology and Experimental Therapeutics·Jean LeFebvreNancy J Brown
Oct 7, 2011·International Journal of Vascular Medicine·Inka LiesmaaKen A Lindstedt
May 21, 2009·Biological Chemistry·Eliete S RodriguesSuma I Shimuta
Dec 8, 2006·Expert Opinion on Therapeutic Targets·Jian Jeffrey Chen, Eileen J Johnson
Nov 2, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alice da Cunha Morales ÁlvaresSonia Maria de Freitas
Apr 28, 2012·Pharmacology & Therapeutics·Domenico RegoliFernand Gobeil
Jan 20, 2009·Peptides·Jérôme CôtéFernand Gobeil
Aug 21, 2013·Expert Opinion on Therapeutic Targets·Nelly Blaes, Jean-Pierre Girolami
May 16, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Elena KashubaLynn Cawkwell
Jan 13, 2015·Vascular Pharmacology·Domenico Regoli, Fernand Gobeil
Nov 2, 2016·BioMed Research International·Bae Huey TeeSau Kuen Lam
Nov 8, 2008·Stroke; a Journal of Cerebral Circulation·Madeleine AustinatChristoph Kleinschnitz
Mar 29, 2007·Nature Clinical Practice. Nephrology·Paolo MadedduSamir El-Dahr
Sep 23, 2008·Chembiochem : a European Journal of Chemical Biology·Artur GieldonHarald Schwalbe
Feb 10, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cécile CaylaMichael Bader
Jun 29, 2007·American Journal of Physiology. Renal Physiology·Yan TanAyad A Jaffa
May 1, 2019·Life Sciences·Thássio Ricardo Ribeiro MesquitaSandra Lauton-Santos

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