Abstract
To examine whether the bradykinin-nitric oxide (NO) pathway directly participates in the antihypertrophic property of angiotensin-converting enzyme (ACE) inhibitors in congestive heart failure, the effects of bradykinin were studied in rat cultured heart cells. Bradykinin (0.1, 1 nM) prevented the phenylephrine-induced increase in protein/DNA content, an index of hypertrophy of heart cells, and amplified the nitrite/nitrate content in the medium. Perindoprilat (1 microM), an ACE inhibitor, also restrained the progression of cardiac hypertrophy and augmented NO release. These effects of perindoprilat were abolished by HOE-140 (kinin B2 antagonist), N omega-nitro-L-arginine (NO synthase inhibitor), and methylene blue (guanylate cyclase inhibitor). Furthermore, there was a significant correlation between protein/DNA content and nitrite/nitrate content. These results indicate that bradykinin inhibits the progression of cardiac hypertrophy due to the increase in NO release and that perindoprilat produces beneficial effects on cardiac hypertrophy by stimulating the bradykinin-NO pathway.
References
Apr 1, 1992·British Journal of Pharmacology·W Linz, B A Schölkens
Mar 1, 1992·British Journal of Pharmacology·R SchulzS Moncada
Jan 1, 1987·Annual Review of Physiology·H E MorganP A Watson
Jun 1, 1985·Circulation Research·P Simpson
Mar 1, 1987·Hypertension·A LückhoffE Bassenge
Oct 1, 1993·Analytical Biochemistry·T P MiskoM G Currie
Jun 16, 1995·The Journal of Biological Chemistry·J L BalligandT Michel
May 1, 1995·Circulation Research·R D MinshallS F Rabito
Feb 1, 1995·Circulation Research·V KolpakovT J Kulik
Jul 1, 1994·British Journal of Pharmacology·K ChibaT Shibano
Sep 1, 1994·Circulation·E O WeinbergB H Lorell
Apr 1, 1994·Hypertension·D J CampbellA M Duncan
Apr 1, 1994·Circulation·T Shibano, P M Vanhoutte
Jun 1, 1994·Hypertension·H NollyA G Scicli
Dec 3, 1993·Cell·J SadoshimaS Izumo
May 1, 1993·The Journal of Clinical Investigation·J L BalligandT W Smith
Dec 15, 1995·Circulation·M RuzickaF H Leenen
Citations
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J A SilvaM Bader
Apr 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Inka LiesmaaKen A Lindstedt
Sep 2, 2008·Canadian Journal of Physiology and Pharmacology·Juan C OsorioSeema Mital
Jun 11, 1999·Japanese Journal of Pharmacology·M MiyazakiS Takai
Aug 5, 2008·Experimental Physiology·Tracey McCauleyJonathan P Folland
Jun 28, 2011·Human Genetics·Li-Jun TanHong-Wen Deng
Dec 31, 2002·Physiological Reviews·Dirk L Brutsaert
May 7, 2010·Journal of Human Hypertension·S JiangX Xu
May 12, 2015·Experimental Physiology·Niwanthi W RajapakseDavid M Kaye
Jun 29, 2007·American Journal of Physiology. Renal Physiology·Julien AllardJean-Pierre Girolami