PMID: 9435601Jan 22, 1998Paper

Role of bradykinin-NO pathway in prevention of cardiac hypertrophy by ACE inhibitor in rat cardiomyocytes

The American Journal of Physiology
Y IshigaiT Shibano

Abstract

To examine whether the bradykinin-nitric oxide (NO) pathway directly participates in the antihypertrophic property of angiotensin-converting enzyme (ACE) inhibitors in congestive heart failure, the effects of bradykinin were studied in rat cultured heart cells. Bradykinin (0.1, 1 nM) prevented the phenylephrine-induced increase in protein/DNA content, an index of hypertrophy of heart cells, and amplified the nitrite/nitrate content in the medium. Perindoprilat (1 microM), an ACE inhibitor, also restrained the progression of cardiac hypertrophy and augmented NO release. These effects of perindoprilat were abolished by HOE-140 (kinin B2 antagonist), N omega-nitro-L-arginine (NO synthase inhibitor), and methylene blue (guanylate cyclase inhibitor). Furthermore, there was a significant correlation between protein/DNA content and nitrite/nitrate content. These results indicate that bradykinin inhibits the progression of cardiac hypertrophy due to the increase in NO release and that perindoprilat produces beneficial effects on cardiac hypertrophy by stimulating the bradykinin-NO pathway.

References

Apr 1, 1992·British Journal of Pharmacology·W Linz, B A Schölkens
Jan 1, 1987·Annual Review of Physiology·H E MorganP A Watson
Oct 1, 1993·Analytical Biochemistry·T P MiskoM G Currie
Jun 1, 1994·Hypertension·H NollyA G Scicli

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Citations

Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J A SilvaM Bader
Apr 21, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Inka LiesmaaKen A Lindstedt
Sep 2, 2008·Canadian Journal of Physiology and Pharmacology·Juan C OsorioSeema Mital
Jun 28, 2011·Human Genetics·Li-Jun TanHong-Wen Deng
May 12, 2015·Experimental Physiology·Niwanthi W RajapakseDavid M Kaye

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