Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding.

Autonomic Neuroscience : Basic & Clinical
Yvette TachéP Q Yuan

Abstract

Pavlov's pioneering work established that sham-feeding induced by sight or smell of food or feeding in dogs with permanent esophagostomy stimulates gastric acid secretion through vagal pathways. Brain circuitries and transmitters involved in the central vagal regulation of gastric function have recently been unraveled. Neurons in the dorsal vagal complex including the dorsal motor nucleus of the vagus (DMN) express thyrotropin-releasing hormone (TRH) receptor and are innervated by TRH fibers originating from TRH synthesizing neurons in the raphe pallidus, raphe obscurus and the parapyramidal regions. TRH injected into the DMN or cisterna magna increases the firing of DMN neurons and gastric vagal efferent discharge, activates cholinergic neurons in gastric submucosal and myenteric plexuses, and induces a vagal-dependent, atropine-sensitive stimulation of gastric secretory (acid, pepsin) and motor functions. TRH antibody or TRH-R1 receptor oligodeoxynucleotide antisense pretreatment in the cisterna magna or DMN abolished vagal-dependent gastric secretory and motor responses to sham-feeding, 2-deoxy-D-glucose, cold exposure and chemical activation of cell bodies in medullary raphe nuclei. TRH excitatory action in the DMN is poten...Continue Reading

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Citations

Jul 8, 2014·Current Opinion in Pharmacology·Andreas Stengel, Yvette Taché
Nov 13, 2008·Pharmacology & Therapeutics·J KamathA Winokur
May 17, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A StengelY Taché
Oct 16, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E M Swartz, G M Holmes
Sep 26, 2012·Advances in Pharmacological Sciences·Naila Rasheed, Abdullah Alghasham
Jan 8, 2015·The Journal of Endocrinology·Patricia Joseph-BravoJean-Louis Charli
Mar 13, 2010·Analytical and Bioanalytical Chemistry·Vlastimil DohnalKamil Kuca
Dec 10, 2014·Endocrinology·Steffen MayerlHeike Heuer
May 28, 2020·Frontiers in Pharmacology·Jean-Louis CharliPatricia Joseph-Bravo
Jul 8, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pu-Qing Yuan, Yvette Taché
Dec 3, 2020·Frontiers in Psychiatry·Alison Accarie, Tim Vanuytsel
May 4, 2021·Frontiers in Cell and Developmental Biology·David M JamesJulia E Dallman

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