Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema.

American Journal of Respiratory Cell and Molecular Biology
Hiroshi MatsuuraChun Geun Lee

Abstract

The exaggerated expression of chitinase-like protein YKL-40, the human homologue of breast regression protein-39 (BRP-39), was reported in a number of diseases, including chronic obstructive pulmonary disease (COPD). However, the in vivo roles of YKL-40 in normal physiology or in the pathogenesis of specific diseases such as COPD remain poorly understood. We hypothesized that BRP-39/YKL-40 plays an important role in the pathogenesis of cigarette smoke (CS)-induced emphysema. To test this hypothesis, 10-week-old wild-type and BRP-39 null mutant mice (BRP-39(-/-)) were exposed to room air (RA) and CS for up to 10 months. The expression of BRP-39 was significantly induced in macrophages, airway epithelial cells, and alveolar Type II cells in the lungs of CS-exposed mice compared with RA-exposed mice, at least in part via an IL-18 signaling-dependent pathway. The null mutation of BRP-39 significantly reduced CS-induced bronchoalveolar lavage and tissue inflammation. However, CS-induced epithelial cell apoptosis and alveolar destruction were further enhanced in the absence of BRP-39. Consistent with these findings in mice, the tissue expression of YKL-40 was significantly increased in the lungs of current smokers compared with the l...Continue Reading

References

Dec 30, 1999·American Journal of Respiratory Cell and Molecular Biology·S D Shapiro
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J WangJ A Elias
Dec 6, 2000·The Journal of Clinical Investigation·Y KasaharaN F Voelkel
Apr 24, 2001·Arthritis and Rheumatism·J S JohansenM Lotz
Jul 13, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ward R RiceTimothy E Weaver
Feb 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Rubin M TuderSonia C Flores
Apr 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Kazutetsu AoshibaAtsushi Nagai
Jun 12, 2003·Experimental Cell Research·Kimi C Nishikawa, Albert J T Millis
Aug 23, 2003·The Journal of Biological Chemistry·Michael RehliStefan W Krause
Feb 11, 2004·Chest·Naoko YokohoriUNKNOWN Respiratory Failure Research Group in Japan
Jun 9, 2004·American Journal of Respiratory and Critical Care Medicine·Andrew ChurgJoanne L Wright
Jun 23, 2004·Journal of Applied Physiology·Kechun TangEllen C Breen
Jun 25, 2004·The New England Journal of Medicine·James C HoggPeter D Paré
Aug 17, 2004·American Journal of Respiratory Cell and Molecular Biology·Yasuhiko KitasatoHisamichi Aizawa
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tao ZhengJack A Elias
Oct 20, 2005·The Journal of Biological Chemistry·Anneliese D ReckliesSuzanne M Bernier
Nov 4, 2005·Proceedings of the American Thoracic Society·William MacNee
Nov 15, 2005·The Journal of Clinical Investigation·Bing MaJack A Elias
Feb 24, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julia S JohansenPaul A Price
Mar 25, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert J HomerJack A Elias
Mar 31, 2006·Respiratory Research·Ingel K DemedtsGuy G Brusselle
Dec 21, 2006·COPD·Dilyara G YanbaevaEmiel F M Wouters
Jan 24, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Min-Jong KangJack A Elias
Mar 30, 2007·The Keio Journal of Medicine·Mayumi KawadaEmiko Mizoguchi
May 18, 2007·American Journal of Respiratory and Critical Care Medicine·Klaus F RabeUNKNOWN Global Initiative for Chronic Obstructive Lung Disease
Nov 16, 2007·The New England Journal of Medicine·Geoffrey L ChuppJack A Elias
Jan 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrew ChurgJoanne L Wright
Apr 12, 2008·The New England Journal of Medicine·Carole OberGeoffrey L Chupp
Jul 11, 2008·Scandinavian Cardiovascular Journal : SCJ·Yongzhong WangJens Kastrup
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Séverine LétuvéMarina Pretolani
Oct 22, 2008·Current Opinion in Immunology·Chun Geun LeeJack A Elias
Oct 29, 2008·Annual Review of Pathology·James C Hogg, Wim Timens
Nov 5, 2008·The Journal of Clinical Investigation·Peter J Barnes
Jun 6, 2009·American Journal of Respiratory Cell and Molecular Biology·Eugene AgapovMichael J Holtzman

❮ Previous
Next ❯

Citations

Apr 9, 2013·Cellular Signalling·Mansi PrakashCecilia Eriksson
Jul 5, 2011·Glycobiology·Simon J NorthStuart M Haslam
May 9, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Gaetano CaramoriKian Fan Chung
May 3, 2012·Proceedings of the American Thoracic Society·Chun Geun LeeJack A Elias
Nov 9, 2010·Annual Review of Physiology·Chun Geun LeeJack A Elias
Sep 16, 2015·American Journal of Respiratory and Critical Care Medicine·Anna J JamesUNKNOWN BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium
Jun 17, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ester CantóManuel Comabella
Sep 23, 2014·The American Journal of Pathology·Xuchen ZhangPatty J Lee
Oct 9, 2012·Journal of Neuropathology and Experimental Neurology·Dafna Bonneh-BarkayStephanie J Bissel
Aug 8, 2013·Respiratory Medicine·Stefano GuerraFernando D Martinez
Apr 5, 2013·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Gülay Ulusal OkyayYasemin Erten
May 5, 2012·Biochemical and Biophysical Research Communications·Mi Na KimMyung Hyun Sohn
Nov 7, 2015·Molecular and Cellular Pediatrics·Ines MackDominik Hartl
Mar 28, 2013·Mediators of Inflammation·Carian E BoorsmaBarbro N Melgert
Jun 30, 2015·The Journal of Clinical Investigation·Yang ZhouJack A Elias
Sep 3, 2013·Experimental Cell Research·Chunyi LiuJuliy M Perelman
Jan 11, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Xin Wang, Guo-Hong Xing
Apr 23, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Seon-Sook HanJae-Woo Kwon
Oct 11, 2011·Pulmonary Pharmacology & Therapeutics·Lynne A Murray
Sep 1, 2017·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Min Ho KimJong Hun Lee
Nov 12, 2016·The European Respiratory Journal·Xiaoping LongFrancesco Bonella
Aug 10, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Eun Ji KwakMyung Hyun Sohn
Aug 28, 2015·Journal of Leukocyte Biology·Stephania Libreros, Vijaya Iragavarapu-Charyulu
Jun 2, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Francesco BonellaUlrich Costabel
May 6, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Natalia PrzysuchaRafal Krenke
Feb 11, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yang ZhouJack A Elias
Nov 18, 2020·Experimental Lung Research·Mario F PerezCheryl Oncken
Apr 13, 2021·Frontiers in Pharmacology·Pamela Velázquez-DíazYang Zhou
Feb 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ayda PouyafarReza Rahbarghazi
Nov 2, 2021·The Journal of Clinical Investigation·Bing MaJack A Elias

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.