PMID: 6109089Jan 3, 1981

Role of bronchial irritant receptors in asthma

Lancet
M G HarriesT S Orr

Abstract

Sulphur dioxide inhaled at low concentration had no detectable effect on forced expiratory volume in one second in non-asthmatic atopic controls, but it induced asthma and increased bronchial reactivity in nine symptomless atopic and non-atopic asthmatic patients. This increased reactivity was inhibited by sodium cromoglycate (SCG) and partly inhibited by atropine. This suggests that SCG, in addition to its ability to stabilise mast cells, may also act on bronchial irritant receptors or directly on smooth muscle in asthmatic patients.

References

Jan 1, 1979·The Journal of Allergy and Clinical Immunology·S LamM Yeung
Sep 1, 1980·British Journal of Pharmacology·M DixonI M Richards
Aug 1, 1980·British Journal of Industrial Medicine·M G HarriesI M O'Brien

Citations

Feb 1, 1985·Clinical Reviews in Allergy·G Kurland, A B Leong
Jan 1, 1990·Molecular Aspects of Medicine·P J Barnes
Jan 1, 1982·Pharmacology & Therapeutics·R J Davies, I Moodley
Jul 1, 1987·Baillière's Clinical Gastroenterology·D Robertson, R Wright
Jul 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A M Edwards
Dec 1, 1994·Clinical Otolaryngology and Allied Sciences·M A BirchallR W Fuller
Dec 1, 1981·Thorax·D J Hendrick, L Fabbri
Sep 1, 1982·Thorax·N M WilsonM Silverman
Apr 1, 1985·Thorax·P S BurgeP A Patchett
Jan 1, 1987·CRC Critical Reviews in Toxicology·A F Gunnison, D W Jacobsen
Feb 1, 1983·Experimental Lung Research·D Lagunoff
Jan 1, 1986·Annals of Emergency Medicine·B S RiggsC Poole
Jan 1, 1985·Chest·I L Bernstein
Apr 1, 1983·Australian and New Zealand Journal of Medicine·R E SchoeffelD A Lindsay
Jan 1, 1984·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C K Naspitz
Jan 1, 1989·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Y BabaK Toyoshima
Jun 1, 1989·British Journal of Clinical Pharmacology·C M Dixon, P J Barnes
Jan 1, 1987·Drug Intelligence & Clinical Pharmacy·S Murphy, H W Kelly
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·J E Selcow

Related Concepts

Asthma
Atropen
Lobar Bronchus Structure
Bronchial Provocation Tests
Bronchial Spasm
Vicrom
Immediate Hypersensitivity
Mast Cell
Inotropism
Smooth Muscle

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