Role of bronchoscopic photodynamic therapy in lung cancer management

Current Opinion in Pulmonary Medicine
Keyvan Moghissi

Abstract

At present there is universal awareness of the role of photodynamic therapy in oncology. There is also a widespread acceptance of its safety and efficacy in its bronchoscopic application for bronchopulmonary malignant neoplasia. It, is therefore, both timely and relevant to present here the current status of bronchoscopic photodynamic therapy in lung cancer based on a critical review highlighting its indications and results. Bronchoscopic photodynamic therapy has emerged as an important treatment in lung cancer. In advanced disease with focus on quality of life, it offers palliation to all patients and survival benefit to a defined subset. In early cases it provides long survival (potential cure). In patients with intraepithelial stage disease, when it can be accurately diagnosed by the use of fluorescence bronchoscopy and endoscopic ultrasonography, the results can match those of surgical resection. In bronchoscopic photodynamic therapy, the endobronchial tumor is presensitized by systemic administration of a sensitizing photochemical. After a time interval, bronchoscopic illumination (exposure to laser light) is performed to achieve cancer necrosis. The prerequisite for bronchoscopic photodynamic therapy is identification and...Continue Reading

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Citations

Dec 1, 2004·Photodiagnosis and Photodynamic Therapy·Aleksander SierońBożena Suwała-Jurczyk
Sep 26, 2012·Photomedicine and Laser Surgery·Ludmila Katherine MartinTanios Bekaii-Saab
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Feb 28, 2009·International Journal of Palliative Nursing·Gail Walker, Jane Andrew Maiden
Jan 6, 2016·Nanoscale·Yiming ZhouZhifei Dai

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