Role of C afferent fibers and monitoring of intravesical resiniferatoxin therapy for patients with idiopathic detrusor overactivity

The Journal of Urology
T YokoyamaHiromi Kumon

Abstract

Resiniferatoxin (RTX) is a specific C fiber neurotoxin which produces desensitization. In this study we performed intravesical RTX therapy in patients with idiopathic detrusor overactivity. In addition we measured the current perception threshold of C and A delta fibers before and after treatment to evaluate clinical significance. The protocol involved an RTX solution (100 ml of 50 nM) instilled in the bladder for 30 minutes. Four men and 6 women 59 to 75 years old were treated. Effects on bladder function were evaluated before and 30 days after treatment by cystometry and Neurometer (Neurotron, Inc., Baltimore, Maryland). Subjective and objective measures included bladder diaries and quality of life before treatment, and 7, 30 and 90 days subsequently. Of the 10 patients 5 noted improvement and 2 of them became dry. The other 5 patients were considered to have stationary symptoms. Mean maximal cystometric capacity +/- SD increased from 229 +/- 108 ml at baseline to 271 +/- 99.5 ml at 30 days (p = 0.04). The mean number of daily episodes of urinary incontinence decreased from 3.5 +/- 2.2 to 2.0 +/- 1.6 (p = 0.008) at 7 days, to 1.9 +/- 1.6 (p = 0.018) at 30 days and to 2.5 +/- 1.7 (p = 0.018) at 90 days. Mean current perception...Continue Reading

References

Nov 1, 1991·The Journal of Clinical Investigation·W D SteersJ B Tuttle
Jul 1, 1990·Journal of the Autonomic Nervous System·W C de GroatJ R Roppolo
Mar 1, 1983·Journal of the Autonomic Nervous System·W C de GroatK Thor
Feb 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·C J FowlerC G Fowler
May 15, 2002·Urology·Francisco Cruz
Dec 21, 2002·Urology·Jacek L Mostwin
Jul 10, 2003·International Urogynecology Journal and Pelvic Floor Dysfunction·Kimberly KentonJ Thomas Benson

❮ Previous
Next ❯

Citations

Nov 9, 2005·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Helge Stormorken, Frank Brosstad
Jun 25, 2014·Urology·Fuat BicerGuiming Liu
Feb 18, 2016·Neurourology and Urodynamics·Nikolaus Veit-RubinVikram Khullar
Dec 6, 2011·Urology·Yasuhiro YamadaFirouz Daneshgari
Jan 15, 2010·Journal of Minimally Invasive Gynecology·Michael HibnerMay Nour
Jan 22, 2008·The Journal of Urology·Robert AbouassalyFirouz Daneshgari
May 15, 2007·The Journal of Urology·Kimberly KentonLinda Brubaker
Jul 25, 2006·Clinics in Geriatric Medicine·Humphrey Atiemo, Firouz Daneshgari
Aug 17, 2006·BJU International·Heinrich Schulte-Baukloh, Helmut H Knispel
Feb 21, 2009·International Journal of Urology : Official Journal of the Japanese Urological Association·Osamu YamaguchiUNKNOWN Neurogenic Bladder Society
Nov 1, 2011·Neurourology and Urodynamics·Gopalan VijayaVik Khullar
Mar 16, 2011·Neurourology and Urodynamics·Lior LowensteinYoram Vardi
Mar 30, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Atsuko FujiharaTsuneharu Miki
Mar 24, 2006·Expert Opinion on Pharmacotherapy·Petros PerimenisAnastasios Athanasopoulos
Jul 13, 2007·Neurourology and Urodynamics·Kimberly KentonLinda Brubaker
Aug 21, 2007·Neurourology and Urodynamics·Francisco Cruz, Paulo Dinis
Oct 5, 2007·Neurourology and Urodynamics·Frederico MascarenhasNilo Leão
Oct 10, 2007·Neurourology and Urodynamics·Teruhiko YokoyamaAtsushi Nagai
Mar 14, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Akira FurutaNaoki Yoshimura
Jul 3, 2021·International Journal of Molecular Sciences·Yi-Hsuan WuYung-Shun Juan
Aug 15, 2021·BJU International·Stéphanie van der LelyUlrich Mehnert

❮ Previous
Next ❯