Role of C-C chemokines in Takayasu's arteritis disease

International Journal of Cardiology
Veena DhawanSanjay Jain

Abstract

Takayasu's arteritis (TA) is a chronic obliterative inflammatory disease. Inflammatory cell infiltration and destruction of the vessel wall in TA strongly suggest that cell mediated immunological mechanisms play an important role in the pathogenesis of this disease. Therefore, in the present study our aim was to focus on the role of chemokines and adhesion molecules in patients with Takayasu's disease. Twenty-one patients with clinically defined TA and 21 healthy control volunteers were recruited by using the standard criteria. Patients with TA were divided into those with clear-cut clinically active or inactive disease based on vasculitis activity score. MCP-1 and hRANTES were significantly increased in patients with TA as compared to controls. MCP-1 and hRANTES values were reliably able to distinguish between patients with active disease vs. subjects in remission. sVCAM-1 levels remained unaltered between patients and controls. C-C chemokines can be used as reliable markers/diagnostic tools in determining the activity of Takayasu's arteritis.

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Citations

May 31, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sampath SanthoshSanjay Jain
Dec 6, 2008·Clinical Rheumatology·Alexandre Wagner Silva de SouzaEmília Inoue Sato
Sep 19, 2015·Modern Rheumatology·Shoichi FukuiAtsushi Kawakami
Dec 12, 2012·International Reviews of Immunology·Dan WenChang-Sheng Ma
Oct 3, 2014·BioMed Research International·Gang WuVeena Dhawan
Aug 8, 2014·Oxidative Medicine and Cellular Longevity·María Elena SotoIsrael Pérez-Torres
Nov 7, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Alaaeldin DawoodShimaa Zewain
Sep 20, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shasha LiuQin Luo
Dec 5, 2006·Current Opinion in Rheumatology·Yoshinori Seko
May 19, 2010·Expert Review of Clinical Immunology·Kathleen Maksimowicz-McKinnon
Nov 11, 2019·Nature Reviews. Rheumatology·Yoshishige MiyabeAndrew D Luster
Feb 3, 2021·Rheumatology International·Jayakanthan KabeerdossDebashish Danda
Jun 4, 2021·Frontiers in Immunology·Xiufang KongLindi Jiang

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