PMID: 7544341May 1, 1995Paper

Role of C fibers in physiological responses to ozone in rats

Journal of Applied Physiology
M JimbaStephanie A Shore

Abstract

The purpose of this study was to evaluate the role of C fibers in airway responsiveness after exposure to ozone (O3) in rats. The role of C fibers in the decreases in heart rate (HR) and core body temperature (Tc) that occur after inhalation of O3 was also examined. Neonatal rats were treated with capsaicin (Cap) or the vehicle used to dissolve capsaicin (Veh). Cap has been shown to cause permanent destruction of C fibers. When they reached adulthood, conscious minimally restrained rats were exposed to 2 ppm O3 or to air for 3 h. Two hours after the cessation of exposure, rats were anesthetized and instrumented for the measurement of pulmonary mechanics and airway responsiveness to inhaled aerosolized methacholine. O3 had no effect on baseline pulmonary conductance (GL) in either Veh or Cap rats but did cause a decrease in dynamic compliance (Cdyn) in Cap rats (P < 0.05). In Cap rats, O3 exposure caused a marked increase in airway responsiveness; the doses of inhaled aerosolized methacholine required to decrease GL and Cdyn by 50% were 6.5-fold and 9.8-fold lower in O3-compared with air-exposed rats (P < 0.005). In contrast, in Veh rats, O3 did not alter responsiveness. During O3 exposure, there was a profound, almost 50%, decr...Continue Reading

Citations

Jun 14, 2000·Journal of Applied Physiology·S A ShoreJ D Laporte
Nov 9, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kirsten C VerheinAllison D Fryer
Aug 4, 1998·Journal of Applied Physiology·T TakebayashiS A Shore
Aug 19, 2008·Environmental Health Perspectives·Ali K HamadeClarke G Tankersley
Dec 24, 2019·Frontiers in Immunology·Stephanie A Shore
Feb 14, 2002·Journal of Applied Physiology·S A ShoreG G Krishna Murthy
Jul 21, 1999·Human & Experimental Toxicology·G D NielsenY Alarie

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