PMID: 8584508Aug 1, 1995Paper

Role of Ca2+ on endotoxin-sensitivity by galactosamine challenge: lipid peroxide formation and hepatotoxicity in zymosan-primed mice

Pharmacology & Toxicology
S Sakaguchi, K Yokota

Abstract

This study was investigated to clarify the role of intracellular Ca2+ following endotoxin treatment (1 mg/kg, intraperitoneally) to D-galactosamine-sensitized mice (400 mg/kg, intraperitoneally), and to observe lipid peroxide levels, an index of hepatotoxicity, in endotoxin/galactosamine (Ga1N)-challenged mice under activation of macrophages, especially Kupffer cells, by zymosan. The liver lipid peroxide level and serum glutamic pyruvic transminase activity in mice 18 hr after administration of endotoxin/Ga1N were markedly higher than those in mice treated only with endotoxin. In spite of an increase in lipid peroxide formation, there was little or no effect of Ga1N administration on xanthine oxidase and superoxide dismutase activities in mice given endotoxin. However, the injection of verapamil (10 mg/kg, subcutaneously) markedly decreased lipid peroxide levels in liver of endotoxin/Ga1N-injected mice. In the mice given a Ca(2+)-deficient diet, lipid peroxide level in liver after endotoxin/Ga1N injection was markedly decreased compared to that in mice fed a normal diet. Administration of dexamethasone (200 micrograms/kg, intraperitoneally) in mice 1 hr before treatment with endotoxin/Ga1N did not induce lipid peroxide formatio...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·C GalanosW Reutter
Feb 22, 1975·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Kallner
Nov 8, 1985·Science·L J Old
Jan 1, 1989·Microbiology and Immunology·S SakaguchiK Yokota
Jul 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y ShiratoriK Kamii
Apr 24, 1986·The New England Journal of Medicine·H Rasmussen
May 1, 1986·The New England Journal of Medicine·H Rasmussen
Jan 1, 1987·Annual Review of Medicine·D C Morrison, J L Ryan
Jan 1, 1985·International Journal of Nuclear Medicine and Biology·M E Daube, R J Nickles
Sep 1, 1985·Cellular and Molecular Neurobiology·J C Torres, N C Inestrosa
Jan 1, 1974·Reviews of Physiology, Biochemistry and Pharmacology·K Decker, D Keppler
Apr 1, 1974·The Journal of Surgical Research·G G NicholasL D Miller
Sep 1, 1970·The Biochemical Journal·A L Lehninger
Nov 1, 1971·Analytical Biochemistry·C Beauchamp, I Fridovich
Jan 1, 1984·Microbiology and Immunology·S SakaguchiO Sakaguchi
Jan 1, 1981·Microbiology and Immunology·S SakaguchiO Sakaguchi
Jan 1, 1981·Microbiology and Immunology·O SakaguchiH Abe

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Citations

May 24, 2011·Journal of Natural Medicines·Balakrishnan AristatileKodukkur Viswanathan Pugalendi
Dec 31, 2003·Journal of Ethnopharmacology·Veereshwarayya Vimal, Thiruvengadam Devaki
Sep 21, 2002·European Journal of Pharmacology·Shuhei SakaguchiMotoaki Takayanagi
Nov 25, 2000·International Journal of Immunopharmacology·S SakaguchiY Takayanagi
Nov 1, 1996·Pharmacology & Toxicology·S SakaguchiY Takayanagi
Nov 26, 2008·Journal of Basic and Clinical Physiology and Pharmacology·Ganesan PushpavalliKodukkur Viswanathan Pugalendi
Jul 13, 2006·FEMS Immunology and Medical Microbiology·Shuhei Sakaguchi, Shinobu Furusawa
Jan 9, 2010·European Journal of Pharmacology·Ganesan PushpavalliKodukkur Viswanathan Pugalendi
Feb 26, 2004·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shuhei Sakaguchi
Aug 5, 2009·Fundamental & Clinical Pharmacology·Balakrishnan AristatileKodukkur Viswanathan Pugalendi
Oct 12, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H K LimM J Chang
Jul 19, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mehmet Emin BüyükokuroğluFatma Göçer
Aug 2, 2017·Journal of Proteome Research·Sheik Abdulazeez SheriffHoracio Pérez-Sánchez

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