Role of cadmium in carcinogenesis with special reference to cancer of the prostate

Environmental Health Perspectives
M Piscator

Abstract

It has been shown in animal experiments that injections of large amounts of cadmium cause sarcoma at injection sites or testicular damage and eventually testicular tumors. Long-term exposure with small doses of cadmium has not caused testicular or prostatic tumors in experimental animals. Epidemiological studies on cadmium-exposed workers have shown excess deaths due to prostatic cancer in at least three independent investigations. All reported cases probably had considerable exposure decades ago, but there are not enough data to permit any dose-response calculations. The general epidemiology of prostatic cancer was not taken into account in any of the studies. A review of recent literature on epidemiology of prostatic cancer has revealed some basic facts. Small latent prostatic cancer has been shown to be as common in areas with low mortality from prostatic cancer as in areas with high mortality. In the U.S. the black population has a much higher death rate from prostatic cancer than the white population. Marital status has also been implied as a factor in the development of prostatic cancer. Black populations in Africa have much lower death rates than blacks in the U.S., which may depend on large differences in dietary habits...Continue Reading

References

Oct 1, 1976·The Journal of Endocrinology·F K HabibS R Stitch
May 1, 1978·Journal of Steroid Biochemistry·F K Habib
Jun 1, 1979·British Journal of Cancer·F K HabibS R Stitch
Mar 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J GellerD de la Vega
Sep 1, 1979·Journal of the National Cancer Institute·V L ErnsterN L Petrakis
Feb 1, 1979·Journal of Medical Microbiology·M I MahmudC W Potter
Mar 1, 1979·British Journal of Cancer·R K RossS P Martin
Feb 1, 1979·Environmental Health Perspectives·T KjellströmB Rahnster
Feb 1, 1979·Environmental Health Perspectives·E AdamssonK Nogawa
Oct 1, 1979·Environmental Research·M H GreeneJ F Fraumeni
Oct 1, 1979·Antimicrobial Agents and Chemotherapy·J J SchentagW J Jusko
Jan 1, 1977·Advances in Experimental Medicine and Biology·L HoutenG Sonnesso
Feb 1, 1978·British Journal of Urology·R Scott, E Aughey
Apr 1, 1978·American Journal of Epidemiology·V L ErnsterW Winkelstein
Jun 9, 1978·Science·V L ErnsterW Winkelstein
Oct 1, 1978·Cancer·J E Enstrom
Nov 15, 1978·Experientia·K P SkandhanY B Mehta
Apr 1, 1976·Cancer·L N Kolonel
Jun 1, 1977·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·D AndjelkovichT Williams
Oct 1, 1977·Journal of the National Cancer Institute·R R WilliamsJ R Goldsmith
Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·N BreslowH Tulinius
Oct 7, 1976·The New England Journal of Medicine·G G GordonC S Lieber
Jan 1, 1976·Annals of the New York Academy of Sciences·R A LemenH P Blejer
Oct 1, 1975·Archives of Environmental Health·K SuminoS Kitamura
Jan 1, 1975·Biochemical Society Transactions·A M Wallace, J K Grant
Oct 1, 1975·Journal of Reproduction and Fertility·G F Nordberg
Mar 1, 1976·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·A J McMichaelP M Tousey
Jun 1, 1974·Biology of Reproduction·C Lindholmer
Jul 5, 1969·Lancet·H Holden
Aug 1, 1973·The Biochemical Journal·A Cryer, W Bartley
May 1, 1973·Journal of the National Cancer Institute·K Akazaki, G N Stemmerman
Aug 1, 1973·The Annals of Occupational Hygiene·L S LevyH S Platt
Mar 1, 1974·Archives of Environmental Health·R R LauwerysD Stanescu
Aug 1, 1974·Journal of the National Cancer Institute·P GreenwaldA K Polan
Aug 1, 1971·Cancer·E L WynderW F Whitmore
May 1, 1971·Australian and New Zealand Journal of Medicine·C I Johnston, F Mendelsohn
Nov 1, 1970·Archives of Environmental Health·M Piscator, B Axelsson
Aug 1, 1971·Archives of Environmental Health·H G PeteringK L Stemmer
Feb 1, 1968·General and Comparative Endocrinology·B Rosoff, C R Martin
Mar 1, 1966·British Journal of Cancer·G Kazantzis, W J Hanbury
Jan 1, 1980·Scandinavian Journal of Urology and Nephrology·B Hølund

❮ Previous
Next ❯

Citations

Apr 1, 1997·British Journal of Urology·P EkmanJ Dich
Sep 1, 1985·British Journal of Industrial Medicine·L GerhardssonP O Wester
Sep 24, 1988·BMJ : British Medical Journal·V BeralG Rose
Apr 1, 1986·British Journal of Industrial Medicine·H KjuusS Langård
Aug 1, 1981·Environmental Health Perspectives·G F Nordberg, O Andersen
Jan 1, 1988·Archives of Toxicology·L Terracio, M Nachtigal
Jan 1, 1987·Cancer Metastasis Reviews·S H SwierengaJ R McLean
Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·L HoffmannC Huckstorf
Jan 1, 1992·Pharmacology & Therapeutics·E T Snow
Jan 1, 1992·Critical Reviews in Toxicology·M P WaalkesR A Barter
Mar 6, 2012·Urologic Oncology·Jeffrey K Mullins, Stacy Loeb
Oct 1, 1995·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·M Ala-Opas, R Tahvonen
Aug 30, 2008·The Science of the Total Environment·Gerald C Lalor
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Mar 29, 1985·Biochemical and Biophysical Research Communications·M M Webber
Jun 1, 1991·Environmental Research·L SaldivarT I Fortoul
May 1, 1994·Toxicology and Industrial Health·O M FaroonR O'Connor
Dec 1, 1982·Biological Trace Element Research·J D Heck, M Costa
Jun 1, 1982·Biological Trace Element Research·J Daniel Heck, M Costa
May 1, 1990·Biological Trace Element Research·P M LindegaardO Andersen
Jan 1, 1987·Environmental and Molecular Mutagenesis·P E Hartman, D C Kuo
Jul 23, 1999·Renal Failure·L M Fels
Nov 30, 2019·Archives of Pharmacal Research·Keiko Taguchi, Thomas W Kensler
Jul 31, 2019·Journal of Cancer Prevention·Srmena Krstev, Anders Knutsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.