Role of calcitonin gene-related peptide and substance P in different models of pain

Cephalalgia : an International Journal of Headache
R GrecoG Nappi

Abstract

Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia. Experimental models have demonstrated that nitroglycerin (NTG)--a nitric oxide donor--provokes a hyperalgesic state, probably via the activation of second-order neurons in the nucleus trigeminalis caudalis. In order to gain further insight into the role of CGRP and SP in different types of experimental pain, we evaluated and compared changes in immunoreactivity (-ir) for these two neuropeptides at different levels of the central nervous system [nucleus trigeminalis caudalis (NTC) and dorsal horns of the lumbar spinal cord] in two animal models of hyperalgesia: systemic NTG administration and formalin test. Following NTG administration, CGRP-ir decreased steadily in the NTC, whereas SP-ir increased transiently. In the lumbar dorsal horns, NTG induced a decrease in SP-ir 1 h after its administration. Formalin injection induced an ipsilateral increase in both CGRP and SP immunostaining at 1 and 2 h in the lumbar dorsal horns. In the NTC, a significant decrease in CGRP-ir was observed at 1 h. The changes in the staining intensities were paralleled by changes in the numbers of CGRP and of SP varicosities in...Continue Reading

Citations

Mar 19, 2011·Proceedings of the National Academy of Sciences of the United States of America·Malin C LagerströmKlas Kullander
Sep 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hélène BeaudryLouis Gendron
Mar 19, 2014·The Journal of Headache and Pain·Rosaria GrecoCristina Tassorelli
Aug 25, 2015·Journal of Neural Transmission·Zsuzsanna BohárÁrpád Párdutz
Feb 21, 2018·Scientific Reports·Hajer JasimMalin Ernberg
Apr 12, 2020·Journal of Oral Rehabilitation·Hajer JasimMalin Ernberg
Aug 26, 2020·Neuropathology and Applied Neurobiology·H R NelvagalJ D Cooper

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