PMID: 9186842May 1, 1997Paper

Role of calcitonin gene-related peptide in the vascular system on the development of the hyperdynamic circulation in conscious cirrhotic rats

Journal of Hepatology
N HoriK Kashima

Abstract

Calcitonin gene-related peptide (CGRP), a potent vasodilator; plays an important role in modulating vascular tone, acting as a noncholinergic nonadrenergic neurotransmitter. The aim of this study was to assess the role of CGRP, present in the vascular system, in the development of the hyperdynamic circulation observed in liver cirrhosis. Two doses of human alpha-CGRP [8-37], a specific antagonist of CGRP, were administered to cirrhotic and controls rats. Hemodynamics were evaluated using radioactive microspheres in conscious animals. To investigate the arterial depressor effect of exogenous CGRP, we constructed a dose-response curve for mean arterial pressure in cirrhotic and control rats by administering human alpha-CGRP. The administration of high-dose human alpha-CGRP [8-37] (300 nmol.kg body weight-1.min-1) significantly increased both the mean arterial pressure (21 +/- 2 vs. 13 +/- 1%, p < 0.01) and total vascular resistance (76 +/- 5 vs. 54 +/- 5%, p < 0.01) in cirrhotic rats, compared to control rats. The splanchnic hemodynamic effects induced by human alpha-CGRP [8-37] were a significant decrease in percent change of portal venous inflow -42 +/- 3 vs. -33 +/- 3%, p < 0.05) and a significant increase in percent change of...Continue Reading

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Citations

Jun 3, 2006·Journal of Gastroenterology·Han-Chieh LinShou-Dong Lee
Aug 23, 2001·Pharmacology & Therapeutics·P W Hadoke
Mar 23, 2000·Journal of Hepatology·J Bosch, J C García-Pagán
Nov 7, 1999·Journal of Hepatology·J H HenriksenF Bendtsen
Mar 15, 2014·World Journal of Gastroenterology : WJG·Massimo BolognesiAngelo Gatta
Nov 18, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·S Møller, J H Henriksen
Jun 27, 2015·Digestive Diseases and Sciences·Søren Møller, Flemming Bendtsen
Nov 18, 2014·World Journal of Gastroenterology : WJG·Søren MøllerFlemming Bendtsen
Feb 21, 2006·World Journal of Gastroenterology : WJG·Soren Moller, Jens H Henriksen
Sep 14, 2007·Scandinavian Journal of Clinical and Laboratory Investigation·J H HenriksenS Møller
Apr 14, 2019·Clinical Journal of Gastroenterology·Botros Shenoda, Joseph Boselli
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc de PerrotShaf Keshavjee

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