PMID: 6166202Jul 1, 1981Paper

Role of calcium and cAMP in the regulation of rat submandibular mucin secretion

The American Journal of Physiology
D O QuissellJ L Lafferty

Abstract

The role of cellular adenosine 3',5'-cyclic monophosphate (cAMP) and calcium in the secretion of [14C]glucosamine-labeled mucins by rat submandibular acinar cells was studied. cAMP appeared to be involved, since 1-methyl-3-isobutylxanthine potentiated the secretory response and cellular cAMP levels increased dramatically following adrenergic stimulation. Furthermore, cAMP analogues were able to elicit a secretory response in the absence of beta-adrenergic receptor activation. Cellular calcium was required for mucin secretion at the level of cAMP action; depletion of cellular calcium by pretreatment with EGTA inhibited the secretory response to both adrenergic stimulation and exogenous cAMP addition, but pretreatment with EGTA did not alter the rise in cellular cAMP induced by norepinephrine. Extracellular calcium was not required to elicit mucin secretion, nor could secretion be elicited by means of the calcium ionophore A23187 alone. However, extracellular calcium may have an important biological role in mucin secretion, since cholinergic receptor activation and alpha-adrenergic receptor activation in conjunction with beta-adrenergic receptor activation potentiated mucin release. In addition, the calcium ionophore A23187 poten...Continue Reading

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Citations

Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M BahroU Pfeifer
Aug 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·R S RedmanK A Barzen
Sep 20, 1993·Annals of the New York Academy of Sciences·B J Baum
Feb 1, 1987·Journal of Dental Research·D O QuissellK A Barzen
Jul 1, 1989·Acta Physiologica Scandinavica·G B SagulinG M Roomans
Dec 1, 1994·In Vitro Cellular & Developmental Biology. Animal·D O QuissellR L McNutt
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P F MaletR D Soloway
Aug 1, 1987·Journal of Dental Research·R M Müller, J R Martinez
Nov 5, 1997·Microscopy Research and Technique·B R MacPherson, R S Pemsingh
Jan 1, 1992·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·D O QuissellF J Dowd
Aug 1, 1986·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·D O QuissellM R Mark
Mar 1, 1987·Bioscience Reports·M A McPherson, R L Dormer
Feb 1, 1983·Journal of Dental Research·D O QuissellK A Barzen
Nov 3, 1987·European Journal of Pharmacology·J HelmanB J Baum
Apr 1, 1984·Cell Calcium·R M Case
Jan 1, 1988·Archives of Oral Biology·A R Shahed, D W Allmann
Sep 24, 2004·Cellular Signalling·Chun Yan MaZong Jie Cui
Oct 15, 1985·Biochemical and Biophysical Research Communications·G B BlumeA D Goldstone
May 29, 1992·Biochemical and Biophysical Research Communications·D K AgrawalB M Boman

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