PMID: 9431849Feb 12, 1998Paper

Role of calcium influx and intracellular calcium stores in angiotensin II-mediated calcium hyper-responsiveness in smooth muscle from spontaneously hypertensive rats

Journal of Hypertension
R M Touyz, E L Schiffrin

Abstract

To investigate post-receptor mechanisms that underlie enhanced angiotensin II (Ang II)-stimulated cytosolic free Ca2+ concentration ([Ca2+]i) responses in vascular smooth muscle cells from small arteries of SHR. To determine whether Ca2+ influx is altered in SHR, effects of Ca2+ channel antagonists (nitrendipine and diltiazem) and depletion of extracellular Ca2+ on Ang II-stimulated [Ca2+]i responses in primary cultured unpassaged vascular smooth muscle cells from mesenteric arteries of spontaneously hypertensive rats (SHR), Wistar and Wistar-Kyoto (WKY) rats aged 17 weeks were studied. To assess whether Ca2+ stores contribute to increases in Ang II-stimulated Ca2+ mobilization and [Ca2+]i in SHR, cells were exposed to thapsigargin, a selective reticular Ca2+-ATPase inhibitor. [Ca2+]i was measured by fura-2 methodology. Basal and 1 nmol/l Ang II-stimulated [Ca2+]i were significantly greater in SHR cells (123 +/- 7.1 nmol/l basal; 268 +/- 7.0 nmol/l stimulated) than they were in those from WKY rats (88 +/- 4.8 nmol/l basal; 221 +/- 8.6 nmol/l stimulated) and Wistar rats (85 +/- 3.0 nmol/l basal; 216 +/- 8.3 nmol/l stimulated). In Ca2+-free medium, basal and Ang II-induced [Ca2+]i were reduced in all groups, but Ang II-stimulated...Continue Reading

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Citations

Aug 21, 2003·Free Radical Biology & Medicine·H Y LinDana R Crawford
Sep 28, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shigang LiZhice Xu
Oct 26, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hong Liu
Jun 6, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yukiko Nomura, Masahisa Asano
Apr 25, 2014·Current Hypertension Reports·Augusto C MontezanoRhian M Touyz
Nov 24, 2004·Clinical and Experimental Hypertension : CHE·Gabrielle GendronDomenico Regoli
Feb 25, 2014·Clinical Science·Claudio M Costa-NetoLucas T Parreiras-E-Silva
Sep 10, 2002·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R M Touyz, C Berry
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ernesto L Schiffrin, Rhian M Touyz
Sep 22, 2001·Hypertension·G E CalleraL M Bendhack
May 11, 2006·Journal of Hypertension·Daoyan LiuMartin Tepel
Apr 25, 2008·American Journal of Physiology. Cell Physiology·Karina ThiemeMaria Oliveira-Souza
Jul 18, 2001·American Journal of Physiology. Renal Physiology·M Salomonsson, W J Arendshorst
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ya-Ping FanSatish Rattan
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·C BerryD G Johns

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