Role of cannabinoid receptor type 1 in rostral ventrolateral medulla in high-fat diet-induced hypertension in rats

Journal of Hypertension
Guo-Qi LiQian Li

Abstract

Stimulation of cannabinoid type 1 (CB1) receptor in the rostral ventrolateral medulla (RVLM) increases renal sympathetic activity (RSNA) and blood pressure (BP) in rats. Thus, we hypothesized that CB1 receptor in the RVLM may play a critical role in the development of obesity-induced hypertension. To this end, we evaluated the levels of endocannabinoids and CB1 receptors in the RVLM in high-fat diet (HFD)-induced hypertensive rats. We then used pharmacological and molecular methods to examine the role of RVLM CB1 receptors in regulation of BP, heart rate (HR), and RSNA in obesity-induced hypertensive rats. We found that HFD-fed rats exhibited higher basal BP, HR, and RSNA than standard diet-fed rats, which were associated with increased levels of endocannabinoids and CB1 receptor expression in the RVLM. Furthermore, unilateral intra-RVLM microinjections of AM251 (0, 100, or 500 nM/0.5 μl/site) dose-dependently decreased BP, HR, and RSNA to a greater extent in HFD-fed rats than in standard diet-fed rats. Finally, siRNA-mediated knockdown of CB1 receptor expression in the RVLM robustly decreased BP, HR, and RSNA in HFD-fed rats. Taken together, our results suggested that enhanced CB1 receptor-mediated neurotransmissions in the RV...Continue Reading

References

Dec 16, 1998·Brain Research·Q J SunP M Pilowsky
Apr 25, 2000·Hypertension·A D DobrianT J Lauterio
Jun 10, 2000·Current Opinion in Nephrology and Hypertension·F C Luft
Aug 27, 2002·Journal of Hypertension·Paul M Pilowsky, Ann K Goodchild
Mar 30, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J-P DesprésN Alméras
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Jul 16, 2008·Behavioural Pharmacology·Christopher S BreivogelRaj K Razdan
Sep 4, 2008·Current Hypertension Reports·Scott H Carlson, J Michael Wyss
Sep 4, 2008·Current Hypertension Reports·Ronald G Victor, Moiz M Shafiq
Aug 12, 2009·Journal of Chemical Neuroanatomy·Ruth L Stornetta
Mar 30, 2010·The Journal of Biological Chemistry·John E HallDavid E Stec
May 10, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Benedek ErdosNihal Tumer
Jan 25, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Seth D DePuyPatrice G Guyenet
Apr 5, 2013·Journal of Biomedical Research·Yaping WangGang Tian
Feb 18, 2016·Journal of Physiology and Biochemistry·François-Xavier GamelinElsa Heyman
Jun 6, 2016·Current Hypertension Reports·Jussara M do CarmoJohn E Hall

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.