Role of cannabis in inflammatory bowel diseases

Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology
Abhilash PerisettiHemant Goyal

Abstract

For many centuries, cannabis (marijuana) has been used for both recreational and medicinal purposes. Currently, there are about 192 million cannabis users worldwide, constituting approximately 3.9% of the global population. Cannabis comprises more than 70 aromatic hydrocarbon compounds known as cannabinoids. Endogenous circulating cannabinoids, or endocannabinoids, such as anandamide and 2-arachidonoyl-glycerol, their metabolizing enzymes (fatty acid amide hydrolase and monoacylglycerol lipase) and 2 G-protein coupled cannabinoid receptors, CB1 and CB2, together represent the endocannabinoid system and are present throughout the human body. In the gastrointestinal (GI) tract, the activated endocannabinoid system reduces gut motility, intestinal secretion and epithelial permeability, and induces inflammatory leukocyte recruitment and immune modulation through the cannabinoid receptors present in the enteric nervous and immune systems. Because of the effects of cannabinoids on the GI tract, attempts have been made to investigate their medicinal properties, particularly for GI disorders such as pancreatitis, hepatitis, and inflammatory bowel diseases (IBD). The effects of cannabis on IBD have been elucidated in several small obser...Continue Reading

Citations

Jun 13, 2020·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Sho SuzukiHisatomo Ikehara
Apr 26, 2020·International Journal of Molecular Sciences·Antonelly Cassio Alves de CarvalhoSandra M Barbalho
Sep 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Seyed Alireza SalamiNitin Mantri
Jun 11, 2021·Advances in Therapy·Megan C BuckleyArun Swaminath
Jul 30, 2021·ImmunoTargets and Therapy·Valeria GiorgiPiercarlo Sarzi-Puttini

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