Role of canonical Wnt signaling/ß-catenin via Dermo1 in cranial dermal cell development

Development
Thu H TranRadhika P Atit

Abstract

Cranial dermis develops from cephalic mesoderm and neural crest cells, but what signal(s) specifies the dermal lineage is unclear. Using genetic tools to fate map and manipulate a cranial mesenchymal progenitor population in the supraorbital region, we show that the dermal progenitor cells beneath the surface ectoderm process canonical Wnt signaling at the time of specification. We show that Wnt signaling/β-catenin is absolutely required and sufficient for Dermo1 expression and dermal cell identity in the cranium. The absence of the Wnt signaling cue leads to formation of cartilage in craniofacial and ventral trunk regions at the expense of dermal and bone lineages. Dermo1 can be a direct transcription target and may mediate the functional role of Wnt signaling in dermal precursors. This study reveals a lineage-specific role of canonical Wnt signaling/β-catenin in promoting dermal cell fate in distinct precursor populations.

References

Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Aug 1, 1992·Archives of Dermatology·R W Goltz
Nov 1, 1995·Developmental Biology·L LiEric N Olson
Aug 4, 1995·Science·M HanksAlexandra L Joyner
Apr 1, 1997·Molecular and Cellular Biology·Veronique LefebvreBenoit de Crombrugghe
Aug 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Q ZhaoBenoit de Crombrugghe
Jan 19, 1999·Annual Review of Cell and Developmental Biology·A Wodarz, R Nusse
Feb 3, 2000·Nature Cell Biology·Paul A Trainor, R Krumlauf
Jun 27, 2000·The Journal of Biological Chemistry·M van BeestH Clevers
Jan 11, 2002·Developmental Biology·Xiaobing JiangGillian Morriss-Kay
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 24, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Y ChaiJ Han
Jan 1, 1958·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M McGEE-RUSSELL
Apr 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R LEV, S S SPICER
May 11, 2004·Genes & Development·Haruhiko AkiyamaBenoit de Crombrugghe
Sep 17, 2004·Nature Reviews. Genetics·Randall T MoonAjamete Kaykas
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Catriona Y Logan, Roel Nusse
Nov 2, 2004·Nature Cell Biology·Karl J L FernandesFreda D Miller
Nov 30, 2005·Journal of Anatomy·Drew M Noden, Paul A Trainor
May 30, 2006·Developmental Biology·Radhika P AtitRonald A Conlon
Jul 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alexandra L Joyner, Mark Zervas
Nov 18, 2006·The Journal of Surgical Research·Erin BowleyBing Siang Gan
Nov 28, 2006·Nature Genetics·Fei LiuSarah E Millar
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ken IwatsukiRobert F Margolskee
Jun 5, 2007·Nature Genetics·Xiaoling WangIgnatia B Van den Veyver
Jun 5, 2007·Nature Genetics·Karl-Heinz GrzeschikRudolf Happle
Aug 3, 2007·Development·Arhat AbzhanovClifford J Tabin
Nov 21, 2007·Developmental Biology·Fei LiuSarah E Millar
Jul 12, 2008·Mechanisms of Development·Toshiyuki YoshidaSachiko Iseki
Dec 20, 2008·BMC Bioinformatics·Kyoung-Jae WonWei Wang
Mar 3, 2009·Genome Research·Michael P SchnetzPeter C Scacheri
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Aug 25, 2009·Developmental Biology·Hwa-Seon Seo, Rosa Serra
Sep 1, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Preethi ManiRadhika P Atit
Apr 16, 2010·Nature·Tae-Kyung KimMichael E Greenberg
Aug 10, 2010·American Journal of Human Genetics·Turgut TukelRobert J Desnick

Citations

Dec 19, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L Henry GoodnoughRadhika P Atit
Oct 11, 2011·Connective Tissue Research·Kevin A Tompkins
Nov 29, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takamitsu MaruyamaWei Hsu
Nov 6, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Leah C BiggsMartine Dunnwald
Oct 24, 2015·Evolution & Development·Francisco FigueroaElizabeth E LeClair
Dec 3, 2014·Mechanisms of Development·I DuranM Marí-Beffa
May 13, 2018·Disease Models & Mechanisms·Linnea SchmidtTrevor Williams
Aug 30, 2018·Genesis : the Journal of Genetics and Development·James W Ferguson, Radhika P Atit
Jun 7, 2016·Genesis : the Journal of Genetics and Development·Isadore BudnickRadhika P Atit
Dec 16, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Venkata ThulabanduRadhika P Atit
Jan 8, 2019·Genesis : the Journal of Genetics and Development·Gregg DiNuoscio, Radhika P Atit
Jan 31, 2019·Scientific Reports·Zhixiang WuJing Li
Jun 1, 2017·The Journal of Craniofacial Surgery·Christopher M Runyan, Kyle S Gabrick
Nov 17, 2020·The Journal of Pathology·Ivy UsanskyTanya J Shaw

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.