Role of cardiac myocyte CXCR4 expression in development and left ventricular remodeling after acute myocardial infarction.

Circulation Research
Udit AgarwalMarc S Penn

Abstract

Stromal cell-derived factor (SDF)-1/CXCR4 axis has an instrumental role during cardiac development and has been shown to be a potential therapeutic target for optimizing ventricular remodeling after acute myocardial infarction (AMI) and in ischemic cardiomyopathy. Although a therapeutic target, the specific role of cardiac myocyte CXCR4 (CM-CXCR4) expression following cardiogenesis and survival of cardiac myocyte and left ventricular remodeling after AMI is unknown. We hypothesized that cardiac myocyte derived CXCR4 is critical for cardiac development, but it may have no role in adulthood secondary to the short transient expression of SDF-1 and the delayed expression of CM-CXCR4 following AMI. To address this issue, we developed congenital and conditional CM-CXCR4(-/-) mouse models. Two strains of CM-CXCR4(flox/flox) mice were generated by crossing CXCR4(flox/flox) mice with MCM-Cre(+/-) mouse and MLC2v-Cre(+/-) mouse on the C57BL/6J background, yielding CXCR4(flox/flox) MCM-Cre(+/-) and CXCR4(flox/flox)MLC2v-Cre(+/-) mice. Studies demonstrated recombination in both models congenitally in the MLC2v-Cre(+/-) mice and following tamoxifen administration in the MCM-Cre(+/-) mice. Surprisingly the CXCR4(flox/flox)MLC2v-Cre(+/-) are ...Continue Reading

References

Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T X O'BrienK R Chien
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·Q MaT A Springer
Sep 10, 1999·Developmental Biology·K E McGrathJ Palis
Jun 8, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Merav Darash-YahanaAmnon Peled
Nov 3, 2004·The Journal of Experimental Medicine·Yuchun NieYong-Rui Zou
Oct 4, 2005·Molecular and Cellular Neurosciences·Veysel OdemisJürgen Engele
Jan 18, 2006·Cell·Carmen Ruiz de AlmodovarPeter Carmeliet
Sep 23, 2006·The New England Journal of Medicine·Volker SchächingerUNKNOWN REPAIR-AMI Investigators
Mar 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Yu MisaoHisayoshi Fujiwara
May 15, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ming ZhangMarc S Penn
May 25, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Raquel Lima e SilvaPeter A Campochiaro
Sep 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Frederic SierroFabienne Mackay
Mar 29, 2008·Stem Cells·Timothy J NelsonAndre Terzic
Apr 30, 2008·Genesis : the Journal of Genetics and Development·Han GerritsJan A Gossen
May 30, 2008·Journal of Neuroimmunology·Richard J MillerBula J Bhattacharyya
Oct 2, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stefan BrunnerWolfgang-Michael Franz
May 23, 2009·Circulation Research·Marc S Penn
Jun 16, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Junming TangYongzhang Huang
Jun 19, 2009·International Journal of Cardiology·Marc S Penn, Udit Agarwal
Feb 6, 2010·The American Journal of Pathology·Jiqiu ChenSima T Tarzami

❮ Previous
Next ❯

Citations

Aug 24, 2010·Journal of Cardiovascular Pharmacology·Thomas J LaRoccaSima T Tarzami
Apr 11, 2008·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Hajime YokotaPhillip C Yang
Mar 9, 2012·Vascular Health and Risk Management·Jane Hoover-Plow, Yanqing Gong
Jan 3, 2012·Journal of Molecular and Cellular Cardiology·William M ChilianLiya Yin
Nov 26, 2010·Seminars in Thoracic and Cardiovascular Surgery·Antoine H ChaanineRoger J Hajjar
Oct 5, 2010·The American Journal of Pathology·Marc S Penn
Jun 7, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Soon Jun HongKeith L March
Aug 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Daniel MasonShilpa Sant
Nov 26, 2011·Journal of the American College of Cardiology·Elisa A LiehnChristian Weber
Nov 26, 2011·Journal of the American College of Cardiology·Nikolaos G Frangogiannis
Mar 5, 2011·Journal of the American College of Cardiology·Yoshiaki KawaseRoger J Hajjar
Jun 27, 2014·Frontiers in Physiology·Yvonne DöringHeidi Noels
Jun 3, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Silke MühlstedtMichael Bader
Jul 2, 2016·Immunology Letters·Tommaso PozzobonBarbara Molon
Sep 16, 2015·Stem Cells Translational Medicine·Yuri M KlyachkinAhmed Abdel-Latif
Oct 19, 2017·Cardiovascular Research·Oliver J ZiffSean M Davidson
Jan 10, 2012·Circulation Research·Matthew Coggins, Anthony Rosenzweig
Jun 23, 2012·Circulation Research·Marc S Penn
May 25, 2011·Circulation. Heart Failure·Sachiko KankiRichard T Lee
Jan 10, 2018·Archivos de cardiología de México·Luis A Lara-MartínezSalomón Hernández-Gutierrez
May 30, 2020·Journal of Cardiovascular Development and Disease·Tyler L StevensPeter J Mohler
Mar 2, 2017·Female Pelvic Medicine & Reconstructive Surgery·Bruna M CouriMargot S Damaser
Mar 16, 2017·Stem Cells Translational Medicine·Salim S HayekAhmed K Abdel-Latif
Nov 1, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Mari MayorgaFeng Dong
May 18, 2020·Journal of Cardiovascular Translational Research·Bijun Chen, Nikolaos G Frangogiannis
Jun 8, 2017·Heart Failure Reviews·Abesh Bera, Dwaipayan Sen
May 11, 2019·International Journal of Molecular Sciences·Thomas J LaRoccaSima T Tarzami
Jun 15, 2021·Frontiers in Immunology·Huating ChenBinghui Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.