Role of catabolite control protein A in the regulation of intermedilysin production by Streptococcus intermedius.

Infection and Immunity
Toshifumi TomoyasuHideaki Nagamune

Abstract

Streptococcus intermedius is an opportunistic pathogen of humans that causes purulent infections, including brain and liver abscesses. This pathogen secretes a human-specific cytolysin, intermedilysin, which has been recognized as a major virulence factor. However, most of the expressional control mechanisms of ily are still unknown. To determine these mechanisms, we analyzed the nucleotide sequence of the ily promoter region. We found a highly homologous region to the catabolite-repressible element (cre) in the ily promoter region and observed a considerable decrease in the amount of secreted intermedilysin when cells were grown in a culture medium containing high concentrations of glucose/utilizable carbohydrates. Disruption of the ccpA gene, which encodes catabolite control protein A, did not induce catabolite repression of ily by glucose/utilizable carbohydrates. In cre mutants, catabolite repression of ily was partially restored, and purified catabolite control protein A bound to an oligonucleotide containing the cre consensus sequence in the ily promoter region. In addition, a prolonged lag phase and slower doubling time of the ccpA mutant cells were observed. Our data show that S. intermedius can modulate ily expression ...Continue Reading

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Citations

Nov 29, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A K Mishra, P-E Fournier
Aug 9, 2011·Cell Stress & Chaperones·Toshifumi TomoyasuHideaki Nagamune
Feb 14, 2013·Genome Announcements·Paul J PlanetAdam J Ratner
Nov 26, 2010·Biochemical and Biophysical Research Communications·Heni SusilowatiYoichiro Miyake
Sep 22, 2018·Microbiology and Immunology·Toshifumi TomoyasuHideaki Nagamune
Jun 15, 2018·Scientific Reports·Richard BauerBarbara Spellerberg
Sep 27, 2018·Scientific Reports·Elyse PaluscioMichael G Caparon
May 28, 2020·Frontiers in Microbiology·Elio IssaSima Tokajian
Jun 4, 2020·Archives of Microbiology·Yoshitoyo KodamaMinoru Sasaki
Oct 1, 2021·Microbiology and Immunology·Atsushi Tabata, Hideaki Nagamune

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