Role of catecholaminergic inputs to the medial prefrontal cortex in local and subcortical expression of Fos after psychological stress

Journal of Neuroscience Research
Sarah J Spencer, Trevor A Day

Abstract

A wide variety of stressors elicit Fos expression in the medial prefrontal cortex (mPFC). No direct attempts, however, have been made to determine the role of the inputs that drive this response. We examined the effects of lesions of mPFC catecholamine terminals on local expression of Fos after exposure to air puff, a stimulus that in the rat acts as an acute psychological stressor. We also examined the effects of these lesions on Fos expression in a variety of subcortical neuronal populations implicated in the control of adrenocortical activation, one classic hallmark of the stress response. Lesions of the mPFC that were restricted to dopaminergic terminals significantly reduced numbers of Fos-immunoreactive (Fos-IR) cells seen in the mPFC after air puff, but had no significant effect on stress-induced Fos expression in the subcortical structures examined. Lesions of the mPFC that affected both dopaminergic and noradrenergic terminals also reduced numbers of Fos-IR cells observed in the mPFC after air puff. Additionally, these lesions resulted in a significant reduction in stress-induced Fos-IR in the ventral bed nucleus of the stria terminalis. These results demonstrate a role for catecholaminergic inputs to the mPFC, in the ...Continue Reading

References

Jun 8, 1991·The Journal of Comparative Neurology·K M HurleyC B Saper
Apr 1, 1991·Archives of Neurology·D B Calne, M J Zigmond
Jan 1, 1988·Annals of the New York Academy of Sciences·A J Dunn
Oct 1, 1973·Acta Physiologica Scandinavica·T HökfeltO Johansson
Jul 1, 1983·Physiological Reviews·S L FooteG Aston-Jones
Aug 21, 1995·The Journal of Comparative Neurology·M M MogaR Y Moore
Apr 1, 1993·Journal of Neuroscience Methods·D W Smith, T A Day
Oct 29, 1993·Annals of the New York Academy of Sciences·T S Gray
Jul 2, 1998·Journal of Neurochemistry·B K Yamamoto, S Novotney
Feb 2, 2000·Neuroscience and Biobehavioral Reviews·D ValloneE Borrelli
Mar 29, 2000·Progress in Brain Research·P E SawchenkoA Ericsson
Dec 6, 2000·Progress in Brain Research·C G Van Eden, R M Buijs
Dec 15, 2000·Progress in Neurobiology·T M Tzschentke

❮ Previous
Next ❯

Citations

Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Abdeslam MouihateQuentin J Pittman
Aug 3, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zhi Yan SuiYoung-Chul Chung
Aug 30, 2008·Autonomic Neuroscience : Basic & Clinical·R A L DampneyL M McDowall
Dec 11, 2007·Behavioural Brain Research·Małgorzata LehnerAdam Płaźnik
Nov 21, 2007·Neuroscience and Biobehavioral Reviews·Eric A StoneDavid Quartermain
May 22, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Eric A StoneDavid Quartermain
Nov 14, 2006·Biochemical Pharmacology·Eric A StoneMichael L Lehmann
Aug 2, 2007·Expert Opinion on Therapeutic Targets·Eric A Stone
Jun 5, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roger A L Dampney

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.