PMID: 9001726Nov 25, 1996Paper

Role of catecholamines in the frontal cortex in the modulation of basal and stress-induced autonomic output in rats

Brain Research
D Funk, J Stewart

Abstract

Exposure of animals to noxious or stressful stimuli increases heart rate (HR) and blood pressure through activation of the autonomic nervous system (ANS) and elicits the release of the catecholamines noradrenaline (NA) and dopamine (DA) in the frontal cortex. Subregions of the frontal cortex, such as the medial frontal cortex (MFC) and agranular insular cortex (AIC) project directly to brainstem nuclei involved in autonomic control. It may be hypothesized that catecholamines in the frontal cortex could influence autonomic output through actions on these descending pathways. To evaluate this hypothesis, the effects of intracortical microinjections of drugs acting at NAergic and DAergic receptors were assessed on an autonomically mediated response, the increase in HR induced by tail pinch, in rats anesthetized with urethane. Intra-MFC or AIC injections of an antagonist of beta-adrenoceptors reduced the magnitude of the HR response to pinch. Injections of an agonist of beta-adrenoceptors into these regions increased basal HR but did not affect the pinch response. Injections of drugs acting at alpha-adrenoceptors were without effect. When injected alone, drugs acting at DAergic receptors did not effect basal HR or the response to p...Continue Reading

Citations

Jul 21, 2004·Journal of Neuroscience Research·Rodrigo Fiacadori TavaresFernando Morgan de Aguiar Corrêa
Feb 16, 2008·Journal of Applied Physiology·Kyunghwa BaekSusan A Bloomfield
Aug 4, 2001·Behavioural Pharmacology·M G LanserA R Cools
Jan 14, 1999·Journal of Veterinary Pharmacology and Therapeutics·S ModricH Derendorf
Nov 5, 2004·The European Journal of Neuroscience·S J McDougallAndrew J Lawrence
Sep 30, 2000·Brain Research. Brain Research Reviews·W J Smeets, A González
Jun 26, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Thatiane De Oliveira SergioFrederic W Hopf
Aug 31, 2021·Neuropharmacology·Samuel W CentanniFrederic W Hopf

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