Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure

The American Journal of Pathology
Valerie R StolbergStephen W Chensue

Abstract

Cigarette smoke (CS)-induced lung injury involves innate immune responses. The activation of innate effector cells is thought to require cross talk with dendritic cells (DCs) and macrophages, but the mediators of interaction are unknown. One candidate, CC chemokine receptor 4 (CCR4), is expressed by innate and adaptive effector cells, and its ligands are produced by DCs and macrophages. Using flow cytometry and confocal microscopy, we defined innate responses of lung myeloid DCs, macrophages, and conventional natural killer (NK) cells in mice exposed to CS over 4 days and examined the contribution of CCR4 using CCR4 knockout (CCR4(-/-)) mice. CS affected populations differently, causing an increase in F4/80(+) macrophages, a reduction in parenchymal CD11c(+)CD11b(+)CD103(-) DCs, but no effect on mucosal CD11c(+)CD11b(-)CD103(+) DCs. CS also induced a population of primed/activated CD69(+) NK cells and bronchoepithelial expression of the stress-related NKG2D receptor-activating protein, retinoic acid early transcript 1. CS-exposed CCR4(-/-) mice were similar to controls regarding effects on DCs and macrophages but displayed substantially impaired NK priming/activation and reduced expression of transcripts for interferon gamma, C...Continue Reading

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Citations

May 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Valerie R StolbergJeffrey L Curtis
Jun 9, 2018·International Journal of Environmental Research and Public Health·Agnieszka StrzelakWojciech Feleszko
Jul 30, 2019·Frontiers in Immunology·Jessica G BorgerMargaret L Hibbs
Jul 6, 2019·Frontiers in Immunology·Baptiste HervierVincent Vieillard
Apr 21, 2018·American Journal of Respiratory and Critical Care Medicine·Donna K FinchChristine M Freeman
Aug 21, 2020·Life Science Alliance·Loka R PenkeMarc Peters-Golden
Mar 7, 2021·International Journal of Molecular Sciences·Anne-Kathrin KnuthAndreas Weigert
Mar 27, 2021·Frontiers in Immunology·Giulia PiaggeschiAlessia Visconti
May 22, 2021·Frontiers in Immunology·Yafei RaoYongchang Sun
Jul 21, 2021·International Journal of Molecular Sciences·Kaschin Jamal JameelJürgen Knobloch
Jun 20, 2021·Molecular Ecology·Diana D Moreno SantillánLiliana M Dávalos

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