Role of CD4+ cytotoxic T lymphocytes in the control of viral diseases and cancer

International Reviews of Immunology
Debora MartorelliRiccardo Dolcetti

Abstract

Our knowledge on the physiological role of CD4(+) T lymphocytes has improved in the last decade: available data convincingly demonstrate that, besides the 'helper' activity, CD4(+) T cells may be also endowed with lytic properties. The cytotoxic function of these effector cells has a relevant role in the control of pathogenic infections and in mediating antitumor immune responses. On these bases, several immunotherapeutic approaches exploiting the cytotoxic properties of CD4(+) T cells are under investigation. This review summarizes available data supporting the functional and therapeutic relevance of cytotoxic CD4(+) T cells, with a particular focus on Epstein-Barr virus (EBV)-related disorders.

References

May 3, 1986·Lancet·M OsameM Tara
Mar 1, 1982·The Journal of Experimental Medicine·J A Keene, J Forman
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A M KrenskyS J Burakoff
Aug 1, 1995·Immunological Reviews·S HahnP Erb
Dec 1, 1994·American Journal of Clinical Pathology·N ColemanM A Stanley
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·B LowinJ Tschopp
Jan 17, 1996·Journal of the National Cancer Institute·N P RestifoS A Rosenberg
Jan 1, 1996·Immunologic Research·D Mauri, W J Pichler
Nov 14, 1997·The Journal of Experimental Medicine·D HamannR A van Lier
Oct 10, 1998·Journal of Virology·J JamesonF A Ennis
Oct 31, 1998·Current Opinion in Immunology·S ShrestaT J Ley
Oct 31, 1998·Current Opinion in Immunology·D M Pardoll, S L Topalian
Dec 22, 1998·The Journal of Experimental Medicine·K HungH Levitsky
Mar 2, 1999·The Journal of Experimental Medicine·R E ToesC J Melief
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·D MumbergH Schreiber
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E J WagarD L Greiner
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G ZengR F Wang
Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·H J BontkesJ M Walboomers
Jan 3, 2001·The Journal of Clinical Investigation·K BickhamR Steinman
Mar 3, 2001·Current Opinion in Immunology·A N HoughtonN E Blachere
Mar 13, 2001·Annual Review of Immunology·L G Guidotti, F V Chisari
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A D BitmansourL J Picker

❮ Previous
Next ❯

Citations

Feb 24, 2012·Journal of Virology·Maria-D NastkeJ Mauricio Calvo-Calle
Apr 9, 2013·PloS One·Steven K HildemannDirk Homann
Aug 17, 2011·Immunotherapy·Sergio A Quezada, Karl S Peggs
Mar 29, 2011·Cancer Immunology, Immunotherapy : CII·Tatiana Salles de Souza MalaspinaAna Paula Campanelli
Mar 28, 2013·Clinical & Developmental Immunology·Pablo A GonzálezAlexis M Kalergis
Apr 28, 2011·Seminars in Immunopathology·Michael Campoli, Soldano Ferrone
Mar 1, 2012·Trends in Parasitology·Romy RazakandrainibeRonan Jambou
Aug 1, 2012·Transfusion·Christiane GrasConstança Figueiredo
Nov 20, 2013·Seminars in Immunology·Hilde Cheroutre, Mohammad Mushtaq Husain
Mar 21, 2017·Current Opinion in Rheumatology·Emanuele Bozzalla Cassione, John H Stone
Feb 7, 2018·Frontiers in Immunology·Aurélie DurgeauFathia Mami-Chouaib
Sep 20, 2011·Cancer Immunology, Immunotherapy : CII·Angelos D GritzapisConstantin N Baxevanis
May 30, 2019·Scandinavian Journal of Immunology·Vinícius de Oliveira BoldriniGiovanna Rosa Degasperi
Jun 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katalin Kis-TothGeorge C Tsokos
Nov 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael L FreemanMarcia A Blackman
Mar 16, 2017·Frontiers in Immunology·Elena MuraroAntonio Rosato
Apr 16, 2014·International Journal of Cancer. Journal International Du Cancer·Yusuke TomitaYasuharu Nishimura
Nov 29, 2016·Journal for Immunotherapy of Cancer·Ioannis F VoutsasConstantin N Baxevanis
Feb 11, 2015·Cancer Immunology Research·Eva KleinEahsan Rasul
May 30, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yusuke TomitaYasuharu Nishimura
Jan 1, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mark A SchroederJohn F DiPersio
Aug 28, 2021·International Journal of Molecular Sciences·Milica Perišić NanutJanko Kos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Biomedicine & Biotechnology
Nikki B Marshall, Susan L Swain
Expert Review of Vaccines
Damien Z Soghoian, Hendrik Streeck
Current Opinion in Immunology
Pablo J van de BergRene van Lier
© 2021 Meta ULC. All rights reserved