PMID: 2492007Jan 1, 1989Paper

Role of CD4+ T-lymphocytes in rejection by mice of fetal pig proislet xenografts

Diabetes
J D WilsonR Ceredig

Abstract

The role of T-lymphocyte subpopulations in the rejection of fetal pig proislet (islet precursor) xenografts in mice was examined with in vivo administration of monoclonal antibodies (MoAbs) to CD4+ (GK 1.5) and CD8+ (49-11.1) T-lymphocyte subsets. The data indicate that the rejection process is T-lymphocyte dependent and mediated by CD4+ T-lymphocytes. The in vivo administration of MoAbs specific for graft-borne pig leukocytes failed to prevent xenograft rejection in fully immunocompetent transplant recipients.

Citations

Nov 5, 1997·Diabetes Research and Clinical Practice·W J TzeS S Cheung
Oct 3, 1999·Xenotransplantation·C J Simeonovic
Dec 16, 1998·Xenotransplantation·C J SimeonovicP D Hodgkin
Jan 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·K FederlinB J Hering
Sep 1, 1994·Transplant Immunology·S MasroorM R First
Jul 4, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F SebilleJ P Soulillou
Mar 20, 2004·Scandinavian Journal of Immunology·L ZhangH Ekberg

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