Role of CD47 in Hematological Malignancies.

Journal of Hematology & Oncology
Entsar EladlHong Chang

Abstract

CD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent "don't eat me" signal to prevent phagocytosis. A growing body of evidence demonstrates that CD47 is overexpressed in various hematological malignancies and its interaction with SIRPα on the phagocytic cells prevents phagocytosis of cancer cells. Additionally, it is expressed by different cell types in the tumor microenvironment and is required for establishing tumor metastasis. Overexpression of CD47 is thus often associated with poor clinical outcomes. CD47 has emerged as a potential therapeutic target and is being investigated in various preclinical studies as well as clinical trials to prove its safety and efficacy in treating hematological neoplasms. This review focuses on different therapeutic mechanisms to target CD47, either alone or in combination with other cell surface markers, and its pivotal role in impairing tumor growth and metastatic spread of various types of hematological malignancies.

References

Aug 31, 2000·Annual Review of Biochemistry·A StrasserV M Dixit
Jun 20, 2001·The Journal of Clinical Investigation·E Brown
Jan 2, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Angela M Anniss, Rosemary L Sparrow
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Partha Pratim Manna, William A Frazier
Apr 12, 2003·The Journal of Biological Chemistry·Laurence LamyAlain Bernard
Aug 5, 2004·The Journal of Biological Chemistry·Julia E BrittainLeslie V Parise
Sep 14, 2004·Leukemia & Lymphoma·Per-Arne Oldenborg
Nov 5, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica Koenigsknecht, Gary Landreth
May 27, 2005·The Journal of Biological Chemistry·Partha P MannaWilliam A Frazier
Dec 13, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ellen M van BeekTimo K van den Berg
Apr 4, 2006·Biochemical and Biophysical Research Communications·Tomomi Ishikawa-SekigamiTakashi Matozaki
Jun 17, 2006·Cancer Science·Masahiko ShinoharaTakashi Matozaki
Jul 13, 2006·The Journal of Biological Chemistry·Jeff S IsenbergDavid D Roberts
Sep 1, 2007·British Journal of Haematology·Jannie M Rendtlew DanielsenThomas Rasmussen
Mar 12, 2008·The Journal of Cell Biology·Richard K Tsai, Dennis E Discher
Oct 7, 2010·The Journal of Biological Chemistry·Sukhbir KaurDavid D Roberts
Dec 24, 2010·Cancer Research·Mark P ChaoRavindra Majeti
Jan 8, 2011·Experimental Hematology·Lucia CataniRoberto M Lemoli
Aug 31, 2011·Cold Spring Harbor Perspectives in Biology·Josephine C Adams, Jack Lawler
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephen B WillinghamIrving L Weissman
Jun 19, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yuhua WangLeaf Huang
Mar 15, 2014·Journal of Biochemistry·Yoji MurataTakashi Matozaki
Apr 15, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hiroki GotoSeiji Okada
Mar 12, 2016·Science·Stephanie C CaseyDean W Felsher
Apr 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Jonathan T SockoloskyK Christopher Garcia
Apr 30, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Emily C PiccioneRavindra Majeti
Nov 3, 2016·The New England Journal of Medicine·Vassiliki A Boussiotis
Nov 20, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Penka S PetrovaRobert A Uger

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Citations

Dec 17, 2020·Cancers·Marlon ArnoneClaudia Lengerke
Mar 13, 2021·Pathology·Andrew D JonesAshok Nambiar
Apr 22, 2021·Journal of Hematology & Oncology·Jing-Zhou HouDelong Liu
Apr 29, 2021·OncoTargets and Therapy·Hasaan HayatPing Wang
May 1, 2021·Cancers·Ewa CendrowiczTomasz P Rygiel
Aug 19, 2021·Journal of Hematology & Oncology·Yingyue LiuXin Wang
Sep 29, 2021·Journal of Hematology & Oncology·Shaoming ZhuChong-Xian Pan
Oct 26, 2021·Advanced Science·Yixiao YangGaoxing Luo

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Methods Mentioned

BETA
xenograft
flow cytometry
transgenic
phage display
MDS
xenografts

Clinical Trials Mentioned

NCT02678338
NCT02641002
NCT02367196
NCT03512340
NCT02663518
NCT03530683
NCT02953509
NCT03527147
NCT03248479
NCT02890368

Software Mentioned

Target Scan prediction

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