Role of cell-cell communication in inhibiting butyric acid-induced T-cell apoptosis

Infection and Immunity
Tomoko Kurita-OchiaiKuniyasu Ochiai

Abstract

We have previously demonstrated that human gingival fibroblasts rescue butyric acid-induced T-cell apoptosis via proinflammatory cytokines such as interleukin 6 (IL-6) and IL-11, which are produced by fibroblasts stimulated with butyric acid. In this study, we determined if T-cell adhesion to human gingival fibroblasts influenced the susceptibility of T cells to butyric acid-induced apoptosis. We have shown that the number of Jurkat T cells adherent to gingival fibroblasts (Gin-1 cells) was significantly increased by the addition of butyric acid. All Jurkat cells that adhered to Gin-1 cells remained viable, while the nonadherent Jurkat cells dropped into apoptosis. The increase in T-cell adhesion to fibroblasts was also observed when Jurkat cells, but not Gin-1 cells, were pretreated with butyric acid. The expression levels of CD44, very late antigen 2 (VLA-2) and VLA-5 but not of leukocyte function-associated antigen 1 (LFA-1) and VLA-4 on Jurkat cells were increased following treatment with butyric acid. Furthermore, pretreatment of butyric acid-sensitized Jurkat cells with monoclonal antibodies against CD44, VLA-2, and VLA-5, but not LFA-1 and VLA-4, followed by coculture with Gin-1 cells inhibited T-cell adhesion to fibrobl...Continue Reading

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Citations

Dec 3, 2015·BMC Complementary and Alternative Medicine·Abdelhafid NaniNaim Akhtar Khan
Jan 29, 2008·Journal of Periodontal Research·S TakigawaK Ito
Jun 17, 2005·Archives of Oral Biology·Jiangyun ShengRobert E Marquis
Oct 21, 2005·Life Sciences·Maria F Cury-BoaventuraRui Curi
Nov 10, 2015·The British Journal of Nutrition·Linda V ThomasJia Zhao
Aug 12, 2014·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kuniyasu Ochiai, Tomoko Kurita-Ochiai
Oct 17, 2021·International Journal of Cancer. Journal International Du Cancer·Xinyi LiuXiaowei Wang

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