Role of cell-matrix contacts in cell migration and epithelial-mesenchymal transformation

Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists
E D Hay

Abstract

Epithelial cells make contact with extracellular matrix via receptors on the basal surface that interact with the basal actin cortex. In 3D matrix, the mesenchymal cell makes contact with matrix all around its circumference via similar receptors. When moving, the fibroblasts is constantly constructing a new front end. We postulate in a 'fixed cortex' theory of cell motility that the circumferential actin cortex is firmly attached to matrix and that the myosin-rich endoplasm slides past it into the continually forming new front end. During epithelial-mesenchymal transformation, the presumptive mesenchymal cell seems to turn on the new front end mechanism as a way of emigrating from the epithelium into the underlying matrix with which it makes 'fixed' contacts. Master genes may exist that regulate the expression of epithelial genes on the one hand, and mesenchymal genes on the other.

References

Mar 12, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M Bernfield, R D Sanderson
Sep 1, 1990·American Journal of Respiratory Cell and Molecular Biology·D D Roberts
Feb 1, 1989·Developmental Biology·J E Fitchett, E D Hay
Jan 1, 1989·Cell Motility and the Cytoskeleton·M E Bilozur, E D Hay
Sep 1, 1989·American Journal of Medical Genetics·E D Hay
Jan 1, 1987·Cell Motility and the Cytoskeleton·A KupferS J Singer
Jan 28, 1986·Biochemistry·H K KleinmanG R Martin
Jul 1, 1987·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L Saxén, H Sariola
Jun 22, 1973·Nature·H E Huxley
Jul 1, 1981·The Journal of Cell Biology·I M HermanT D Pollard

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Citations

Feb 18, 1998·International Journal of Cancer. Journal International Du Cancer·Y HayashidoH Rochefort
Sep 1, 1995·Cancer Metastasis Reviews·K MatsumotoR H Kramer
Nov 1, 1995·Digestive Diseases and Sciences·H PaimelaW Silen
Feb 18, 1998·In Vitro Cellular & Developmental Biology. Animal·S S Maria, M L Wada
Oct 21, 2000·Mechanisms of Ageing and Development·J P MansellJ R Sandy
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·P A Appeddu, B D Shur
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Apr 16, 2004·Breast Cancer Research : BCR·Kimberly A BrownHarold L Moses
Apr 2, 2010·Annals of Surgical Oncology·Masaaki IwatsukiMasaki Mori
Jan 6, 2010·EMBO Molecular Medicine·Jose Miguel López-Novoa, M Angela Nieto
Jul 17, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ali Nawshad
Jul 17, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jennifer C Kasemeier-KulesaPaul M Kulesa
Sep 29, 2006·Colloids and Surfaces. B, Biointerfaces·Yuanfang Liu, Shaopeng Wang
May 12, 2006·Periodontology 2000·P Mark BartoldMalcolm L Snead
Mar 25, 2015·Journal of Ophthalmology·Makoto IshikawaTakeshi Yoshitomi
Jun 20, 2006·Current Topics in Developmental Biology·Andras CzirokBrenda J Rongish
Nov 1, 1995·Teratology·C M GriffithE J Sanders
Jun 15, 1993·Microscopy Research and Technique·A O Welsh
Jan 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A NadeauR Blouin
Jun 22, 2011·Nature Reviews. Urology·Jones T Nauseef, Michael D Henry
May 15, 2002·Radiation Research·Chang-Mo KangYun-Sil Lee
Dec 17, 2009·Expert Opinion on Therapeutic Targets·Joerg SchwockDavid W Hedley
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S FrameA Balmain
Jan 26, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jiaqiang DongDaiming Fan
Dec 19, 2017·Experimental Cell Research·Caitlin M LoganA Sue Menko

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