Role of cell proliferation in regenerative and neoplastic disease

Toxicology Letters
S M Cohen

Abstract

DNA replication does not have 100% fidelity. Consequently, a chemical can increase the risk of cancer either by directly damaging DNA (genotoxic) or by increasing the number of cell replications, or both. Increased cell proliferation can be produced by increasing cell births (by direct mitogenesis or regeneration following toxicity), or decreasing cell deaths (by inhibiting apoptosis or differentiation). Cell proliferation can affect the dose-response curve for genotoxic carcinogens and is the basis for carcinogenicity by nongenotoxic agents. Bladder carcinogens will be used to illustrate these mechanisms, and their implications with respect to human risk assessment will be presented.

References

Nov 1, 1992·Chemical Research in Toxicology·S M Cohen, L B Ellwein
Jan 1, 1992·Pharmacology & Therapeutics·F P Guengerich
Jun 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y HommaS Nagase
Aug 31, 1990·Science·S M Cohen, L B Ellwein
Sep 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G J BurinR N Hill
Dec 23, 1994·Science·P Modrich
Feb 1, 1995·Carcinogenesis·S M CohenL L Arnold

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Citations

May 14, 2005·Mutation Research·Heidrun Ellinger-ZiegelbauerHans Juergen Ahr
Mar 1, 2002·Toxicology Letters·R A Ettlin, D E Prentice
Aug 7, 2002·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M E MeekM Walker
May 22, 2001·Environmental Health Perspectives·R T RileyA H Merrill
Nov 24, 2007·Pharmacogenomics·Raoul FrijtersJan Polman
Apr 15, 2016·Expert Opinion on Drug Discovery·P A OliveiraR Pinto-Leite
Sep 1, 2008·Obstetric Medicine·Eleftheria LefkouBeverley J Hunt
Oct 27, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert L Brent

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