Role of central NO-cGMP pathway in vasopressin and oxytocin gene expression during sepsis

Peptides
Gabriela Ravanelli Oliveira-PelegrinMaria José Alves Rocha

Abstract

Sepsis induces massive production of inflammatory mediators, such as nitric oxide (NO), and causes neuroendocrine and cardiovascular alterations. This study investigates the involvement of the central NO-cGMP pathway in arginine vasopressin (AVP) and oxytocin (OXY) gene expression during sepsis induced by cecal ligation and puncture (CLP). Male Wistar rats received an i.c.v. injection of ODQ (0.25 μg/μL), a selective inhibitor of the heme site of soluble guanylate cyclase, or of 1% dymethilsulfoxide (DMSO), as vehicle. Thirty minutes after the injections, sepsis was induced by cecal ligation and puncture or the animals were sham operated. The ODQ pre-treatment did not alter the progressive NO increase observed after CLP. In the supraoptic nucleus (SON), this pretreatment increased the relative gene expression ratio of AVP and OXY in the initial phase of sepsis, but in the late phase, the gene expression of both hormones was reduced. In the paraventricular nucleus (PVN), soluble guanylate cyclase inhibition caused an even larger decrease in the relative gene expression ratio of AVP and OXY during sepsis. These results are indicative of a role of the NO-cGMP pathway in hormonal synthesis in the SON and PVN of the hypothalamus dur...Continue Reading

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Dec 17, 2008·Neuroimmunomodulation·Gabriela Ravanelli Oliveira-PelegrinMaria José Alves Rocha

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Citations

May 18, 2013·Journal of Chemical Neuroanatomy·E SendemirG F Jirikowski
Nov 28, 2012·Neuroimmunomodulation·Gabriela Ravanelli Oliveira-PelegrinMaria José Alves Rocha
Dec 24, 2013·Journal of Neuroimmunology·Gabriela R Oliveira-PelegrinMaria José A Rocha
Dec 30, 2015·Journal of Neuroimmunology·Mike Yoshio HamasakiFabiano Pinheiro da Silva
Jul 18, 2015·Molecular Neurobiology·Fazal WahabMaria Jose A Rocha
Apr 16, 2013·Peptides·Fabiano Pinheiro da SilvaIrineu Tadeu Velasco
Mar 26, 2013·Journal of Neuroimmunology·Gabriela Ravanelli Oliveira-PelegrinMaria José Alves Rocha
Jan 17, 2017·Pituitary·Camila Henriques CoelhoMaria José Alves da Rocha
Jun 8, 2017·Pituitary·Nilton Nascimento Santos-JuniorMaria José Alves Rocha
Sep 6, 2013·Inflammation·Fabiano Pinheiro da SilvaHeraldo Possolo de Souza

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