Role of chlorogenic acid in the toxicity induced by Chinese herbal injections

Drug and Chemical Toxicology
Bao-Qiu LiHua Zhao

Abstract

Adverse reactions induced by Chinese herbal injections have been frequently reported. However, the precise causes of these adverse reactions are not yet fully understood. The aim of the present study was to determine the role of chlorogenic acid (a ubiquitous component of Chinese herbs) in the toxicity of Chinese herbal injections. Beagle dogs were given chlorogenic acid, Yuxingcao injection, or Qingkailing injection (the latter two both containing chlorogenic acid) by intravenous (i.v.) injection, once a day for 7 or 9 days. The systemic toxicity was evaluated. An additional ultrastructural observation on liver and kidney was performed. Anaphylactoid reactions were obvious in dogs treated with Yuxingcao injection. Varying degrees of ultrastructural changes in liver and kidney were observed in the treated dogs, especially in dogs treated with Chinese herbal injections. Our study has led to the view that chlorogenic acid is not an allergen when administrated by i.v. injection, but liver and kidney injury induced by Chinese herbal injections can be partly attributed to chlorogenic acid.

References

Jan 1, 1968·International Archives of Allergy and Applied Immunology·L L LaytonT A Cortese
Apr 1, 1984·Agents and Actions·P T Peachell, F L Pearce
Dec 3, 1999·Antimicrobial Agents and Chemotherapy·H ShutoR Oishi
Nov 6, 2001·Journal of Ethnopharmacology·A Andrade-Cetto, H Wiedenfeld
Feb 14, 2002·Scandinavian Journal of Immunology·A C M BoonA D M E Osterhaus
Jul 26, 2002·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Chikaku DogasakiMasafumi Fukuyama
Sep 5, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Chanan-KhanF M Muggia
Oct 21, 1961·Nature·S O FREEDMANA H SEHON
Mar 1, 1964·The Journal of Allergy·S O FREEDMAN
Mar 1, 1964·The Journal of Allergy·S O FREEDMAN
Oct 22, 2004·Immunological Investigations·Jian GongSwey-Shen Chen
Jan 17, 2007·Trends in Neurosciences·Andreas T Schaefer, Troy W Margrie

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Citations

Mar 10, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhixin ZhangXiaoyan Gao
Sep 15, 2018·Experimental and Therapeutic Medicine·Wen-Yuan DuYu-Bin Zhao

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