Role of cholecystokinin and its antagonist proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L

Physiology & Behavior
V C RubioJ A Madrid

Abstract

Teleost fish are able to adjust their energy intake when fed on pure macronutrient sources, although the exact mechanisms regulating macronutrient selection remain unknown. Since cholecystokinin (CCK) has been reported to modify macronutrient selection patterns in mammals, we explored the effect of CCK administered orally to European sea bass on the selection of separately encapsulated macronutrients. CCK doses of 0.05, 0.15 and 0.25 mg/kg BW administered in gelatine capsules for 5 consecutive days produced a significant inhibition of total food intake (21, 28 and 51%, respectively) at highest doses, evenly reducing the quantity of all the macronutrients ingested and, without affecting their relative proportions in the diet. Oral administration of proglumide, a non-specific CCK receptor antagonist, at doses of 5, 15 and 25 mg/kg BW, induced a quantitative total food intake increase of 2, 18 and 44%, respectively, and an increase of 52% in CH and 43% in P quantity ingested at highest dose. Co-administration of proglumide (25 mg/kg BW) and CCK (0.25 mg/kg BW) in a single preload capsule blocked the effects observed with CCK alone. In conclusion, orally administered CCK induced an anorexigenic effect on both total food and single ...Continue Reading

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Citations

Mar 1, 2012·General and Comparative Endocrinology·Brian C PetersonBrian C Small
Apr 8, 2015·Journal of Animal Physiology and Animal Nutrition·H Volkoff
Aug 21, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Robert TillnerBernd Ueberschär
Jun 9, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·A B TinocoM J Delgado
Jan 24, 2017·Frontiers in Neuroscience·Marta Conde-Sieira, José L Soengas
May 2, 2017·Frontiers in Endocrinology·Ivar RønnestadHélène Volkoff
Jun 20, 2020·Anais Da Academia Brasileira De Ciências·Carlos E BarriosDavid R HernÁndez
Dec 15, 2020·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Neda GilannejadManuel Yúfera

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