Role of cholecystokinin in relaxation of the proximal stomach

Scandinavian Journal of Gastroenterology
P J van der SchaarA A Masclee

Abstract

Ingestion of a meal causes proximal gastric relaxation (accommodation). The magnitude of accommodation is related to the fat content of the meal. A role for cholecystokinin (CCK) has been suggested. However, under fasting conditions intravenous CCK to postprandial levels does not induce a similar accommodation. This study further explores the role of CCK in accommodation. A gastric barostat was used in eight healthy persons to study accommodation in response to a carbohydrate meal with intravenous CCK (CH-CCK), carbohydrate meal with intravenous placebo (CH-placebo) and a fat rich meal with intravenous placebo (FAT). VAS scores for satiety and plasma CCK levels were obtained. In the first postprandial hour the FAT meal induced a relaxation of 112 +/- 29 ml, the CH-CCK meal 49 +/- 36 ml and the CH-placebo meal 12 +/- 32 ml (FAT versus CH-placebo P = 0.03; FAT versus CH-CCK P = 0.09). In the second postprandial hour, intragastric bag volume returned to baseline with all meals. The FAT meal had the most pronounced effect with respect to satiety, CH-placebo the least. In the first postprandial hour, plasma CCK levels increased with the CH-CCK and FAT meals but not with the CH-placebo meal; in the second postprandial hour, levels re...Continue Reading

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Citations

Sep 26, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·P J van der SchaarA A M Masclee
Jul 13, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Emma Janet CastilloAlan R Zinsmeister
Sep 13, 2002·American Journal of Veterinary Research·Mireia Lorenzo-FiguerasAlfred M Merritt
Dec 6, 2006·American Journal of Veterinary Research·Mireia Lorenzo-Figueras, Alfred M Merritt
Dec 23, 2003·The American Journal of Gastroenterology·Isabelle Le Blanc-LouvryPhilippe Ducrotté
Jun 7, 2005·American Journal of Veterinary Research·Mireia Lorenzo-FiguerasAlfred M Merritt
Dec 1, 2006·Nutrition Research Reviews·P GuilloteauR Zabielski

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